大剂量静脉注射人免疫球蛋白联合纳洛酮治疗儿童重症病毒性脑炎疗效研究  

Effects of High-dose Intravenous Injection of Human Immunoglobulin Combined with Naloxone on Severe Viral Encephalitis in Children

作　　者：吕秀丽 王翔 刘伟 Lü Xiu-li;WANG Xiang;LIU Wei(Department of Emergency Pediatrics,Zhumadian Central Hospital,Zhumadian 463000,China;Department of Pediatric Internal Medicine,the First People s Hospital of Zhumadian,Zhumadian 463000,China)

机构地区：[1]驻马店市中心医院急诊儿科,驻马店463000 [2]驻马店市第一人民医院儿内科,驻马店463000

出　　处：《中国合理用药探索》2021年第7期45-48,共4页Chinese Journal of Rational Drug Use

摘　　要：目的:探究大剂量静脉注射人免疫球蛋白联合纳洛酮治疗儿童重症病毒性脑炎的临床疗效。方法:选取2018年9月~2019年9月本院收治的110例重症病毒性脑炎患儿作为研究对象,按照随机数字表法将其分为观察组与对照组,各55例。对照组予以纳洛酮治疗,观察组在对照组基础上予以大剂量静脉注射人免疫球蛋白治疗。观察比较两组临床疗效、症状改善时间、神经功能[神经生长因子(NGF)、S-100β蛋白、神经元特异性烯醇化酶(NSE)]、免疫功能[免疫球蛋白G(IgG)、免疫球蛋白M(IgM)]。结果:观察组总有效率(96.36%)高于对照组(83.64%,P<0.05)。观察组退烧、抽搐消失、意识恢复、呕吐消失、头痛消失时间短于对照组(P<0.05)。治疗后,两组NGF、S-100β蛋白、NSE水平低于治疗前,且观察组低于对照组(P<0.05)。治疗后,两组IgG水平高于治疗前,且观察组高于对照组(P<0.05);两组IgM水平比较无统计学差异(P>0.05)。结论:大剂量静脉注射人免疫球蛋白联合纳洛酮可改善重症病毒性脑炎患儿神经功能、临床症状、免疫功能,疗效确切,值得临床应用与推广。Objective:To explore the clinical efficacy of high-dose intravenous injection of human immunoglobulin combined with naloxone on severe viral encephalitis in children.Methods:110 children with severe viral encephalitis treated from September 2018 to September 2019 in our hospital were selected as research subjects,and they were divided into the observation group and the control group according to the random number table method,55 cases in each group.The control group was treated with naloxone,and the observation group was treated with high-dose intravenous injection of human immunoglobulin on the basis of the control group.The clinical efficacy,time of symptom improvement and neurological function[nerve growth factor(NGF),S-100βprotein and neuron specific enolase(NSE)],immune function[immunoglobulin G(IgG)and immunoglobulin M(IgM)]were observed and compared between the two groups.Results:Total effective rate in the observation group(96.39%)was higher than that in the control group(83.64%,P<0.05).Time of fever,convulsion,consciousness recovery,vomiting and headache disappearance in the observation group was shorter than that in the control group(P<0.05).After treatment,the levels of NGF,S-100βprotein and NSE in the two groups were lower than before treatment,and the observation group were lower than the control group(P<0.05).After treatment,the level of IgG in the two groups was higher than before treatment,and the observation group was higher than the control group(P<0.05).There was no significant difference in the level of IgM between the two groups(P>0.05).Conclusion:The high-dose intravenous injection of human immunoglobulin combined with naloxone can effectively improve the neurological function,clinical symptoms and immune function of children with severe viral encephalitis,with definite curative effect.It is worthy of clinical application and promotion.

关 键 词：重症病毒性脑炎 纳洛酮 人免疫球蛋白 儿童 疗效 

分 类 号：R978[医药卫生—药品]