正常比格犬ABR与ASSR的研究  

A Study on ABRs and ASSRs in Normal Beagle Dogs

作　　者：朱崇元 魏兴梅 赵勇 高志强[2] 冯国栋 ZHU Chongyuan;WEI Xingmei;ZHAO Yong;GAO Zhiqiang;FENG Guodong(Department of Otorhinolaryngology,Weifang Medical University,Weifang,261053,China;Department of Otohinolaryngology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China)

机构地区：[1]潍坊医学院耳鼻咽喉科,潍坊261053 [2]中国医学科学院北京协和医学院北京协和医院耳鼻喉科,北京100730

出　　处：《中华耳科学杂志》2021年第4期647-651,共5页Chinese Journal of Otology

基　　金：北京市科委重点基金(Z191100007619040);首都卫生发展专项(CFH2020-2Z-40115)。

摘　　要：目的探究正常比格犬的短声听性脑干反应(click Auditory Brainstem Response,c-ABR)和听性稳态反应(Auditory steady-state response,ASSR)的正常值。与人的c-ABR与ASSR进行比较,为临床试验提供听力学基础。方法对6只正常比格犬(12耳)麻醉后进行c-ABR和ASSR测试,记录c-ABR的波形、反应阈、潜伏期和波间期以及ASSR的0.5、1、2和4 kHz的反应阈,记录并比较这两种测试方法的阈值。结果比格犬的c-ABR阈值为27.1±10.1 dB nHL,80 dB nHL时Ⅰ波潜伏期平均为1.09±0.1ms,振幅为1.98±1.2μV;Ⅱ波的潜伏期平均为1.98±0.11ms,振幅为1.3±0.65μV,Ⅴ波的潜伏期为3.74±0.32ms,振幅为1.45±0.88μV,Ⅰ-Ⅴ波间期为2.65±0.31ms。ASSR的500 Hz、1 kHz、2 kHz、4 kHz的阈值分别为55.42±11.48 dB HL、57.83±11.48 dB HL、48.75±13.34 dB HL、37.5±10.11 dB HL。结论比格犬c-ABR波形与人相比,潜伏期较人的短,Ⅱ波振幅高,V波振幅低,两者振幅相反。比格犬ASSR的阈值较高频率低于较低频率,其ASSR 4 kHz的阈值更接近c-ABR的阈值。Objective To report thresholds of click evoked auditory brainstem responses(c-ABRs)and auditory steady-state responses(ASSRs)in healthy dogs,in comparison with human c-ABRs and ASSRs,to provide a basis for clinical use.Methods Six normal beagle dogs(12 ears)were anesthetized and for c-ABR and ASSR testing.c-ABR waveforms,response thresholds,latencies and interval latencies,and ASSR thresholds at 0.5,1,2 and 4 kHz were recorded and compared.Results c-ABR threshold was 27.1±10.1 dB nHL.At 80 dB nHL,the latencies of wave Ⅰ,waveⅡ,wave Ⅴ and Ⅰ-Ⅴ interval were 1.09±0.1 ms,1.98±0.11 ms,3.74±0.32 ms and 2.65±0.31 ms,respectively.The amplitudes of wave Ⅰ,wave Ⅱ and wave Ⅴ were 1.98±1.2μV,1.3±0.65μV and 1.45±0.88μV,respectively.ASSR thresholds at 500 Hz,1 kHz,2 kHz and 4 kHz were 55.42±11.48 dB HL,57.83±11.48 dB HL,48.75±13.34 dB HL and 37.5±10.11 dB HL,respectively.Conclusion Compared with human,c-ABR latencies in beagle dogs are shorter,waveⅡamplitude is higher and wave V amplitude is lower.ASSR thresholds at higher frequencies are lower than at lower frequencies in beagle dogs,and thresholds at 4 kHz are closer to that of c-ABR.

关 键 词：听性脑干反应 听性稳态反应 犬 阈值 听力测试 

分 类 号：R764[医药卫生—耳鼻咽喉科]