Chemical and physical variations of cannabis smoke from a variety of cannabis samples in New Zealand  

作　　者：Thomas J.Sheehan Hilary J.Hamnett Richard Beasley Paul S.Fitzmaurice 

机构地区：[1]Toxicology,Institute of Environmental Science and Research(ESR),Porirua,New Zealand [2]Medical Research Institute of New Zealand,Wellington,New Zealand [3]Toxicology Unit,Imperial College London,London,UK. [4]Gribbles Veterinary,Palmerston North,New Zealand

出　　处：《Forensic Sciences Research》2019年第2期168-178,共11页法庭科学研究（英文）

基　　金：supported by the Institute of Environmental Science and Research(ESR)and the Medical Research Institute of New Zealand(MRINZ).

摘　　要：Studies have compared the chemical properties of tobacco smoke to those of cannabis smoke,with the objective of identifying the chemical attributes responsible for the mutagenicity and carcinogenicity of cannabis smoke.Comparative studies have included small sample sizes and produced conflicting results.The aim of this study was to assess the major chemical and physical variations of cannabis smoke across a range of cannabis samples of different potencies and origins,sourced from the illegal market in New Zealand.Twelve cannabis samples were studied ranging from 1.0%to 13.4%delta-9-tetrahydrocannabinol(D9THC)content.A smoking machine was used to smoke“joints”(cannabis cigarettes)and the chemical/physical properties of the smoke assessed.The chemical constituents of the smoke extracts were analysed by gas chromatography/mass spectrometry.A range of different chemical constituents(in addition to D9THC)were identified and their concentrations estimated.Terpenoids were identified as the major variable in cannabis smoke,showing a 40-fold range in total terpenoid content.Analysis of the total particulate matter showed that significantly different levels of particulate matter were produced between the different cannabis samples,ranging from 14.6 to 66.3 mg/g of cannabis smoked.The D9THC delivery efficiency during smoking was also investigated and produced consistent results showing a mean and median of 12.6%and 10.8%,respectively,of the theoretically available D9THC(ranging from 7.2%to 28.0%).

关 键 词：Forensic science forensic toxicology CANNABIS SMOKE delta-9-tetrahydrocannabinol TERPENOIDS gas chromatography/mass spectrometry total particulate matter 

分 类 号：F42[经济管理—产业经济]