载脂蛋白E基因多态性与房性心律失常的关系  

Association between ApoE gene polymorphism and atrial arrhythmia

作　　者：聂娣 娄焕堃 邢团结 梅佳慧 王勋 李鹏 王飞翔 汪明琅 王怡练[2] NIE Di;LOU Huankun;XING Tuan-jie;MEI Jiahui;WANG Xun;LI Peng;WANG Feixiang;WANG Minglang;WANG Yilian(Department of Cardiology,the People′s Hospital of Guanyun County,Guanyun 222202,China;不详)

机构地区：[1]连云港市灌云县人民医院心血管内科,江苏灌云222202 [2]连云港市第二人民医院心血管内科,江苏连云港222006

出　　处：《实用医学杂志》2021年第15期1948-1952,共5页The Journal of Practical Medicine

基　　金：江苏省高层次卫生人才“六个一工程”拔尖人才科研项目(编号:LGY2017065);江苏省“六大人才高峰”高层次人才选拔培养项目(编号:WSN-247)。

摘　　要：目的从基因水平对房性心律失常进行研究,分析载脂蛋白E(ApoE)基因型、表型与房性心律失常的关系。方法选取房性期前收缩、房性心动过速、心房扑动、心房颤动患者120例,同期健康志愿者120例为对照,进行ApoE基因多态性检测并进行统计学分析。结果两组在年龄、高血压、LAD、LVEF方面差异有统计学意义(P<0.05);房性心律失常组较对照组ε3/ε3基因型明显减少,ε3/ε4和ε4/ε4基因型明显增多(P<0.05);两组ApoE2型分布差异无统计学意义(P>0.05);房性心律失常组ApoE3型表达较对照组明显减少,ApoE4型表达明显增多(P<0.05);房颤组较其他房性心律失常组ApoE2型比例减少,ApoE4型比例明显增多(P<0.05);ApoE基因多态性为房性心律失常发生的独立预测因素。结论房性心律失常的发生与ApoE基因表达多态性具有一定关联性,ApoE4可能是导致房性心律失常的敏感表型。Objective To study the correlation between ApoE gene polymorphism and atrial arrhythmias,Methods The patients with atrial extrasystole,atrial tachycardia,atrial flutter and atrial fibrillation were selected as atrial arrhythmia group and 120 healthy outpatients(sinus rhythm)as control group.ApoE gene polymorphism was detected by gene chip detection,and the data were statistically analysed.Results There were significant differences in age,history of hypertension,LAD and LVEF between the two groups.The level ofε3/ε3 genotype in the atrial arrhythmia group was significantly lower than that in the control group,while the level of theε3/ε4 andε4/ε4 genotypes were significantly higher in the atrial arrhythmia group(P<0.05).There was no significant difference in the distribution of ApoE2 type between the atrial arrhythmia group and the control group(P>0.05).The expression of ApoE3 type in the atrial arrhythmia group was significantly lower than that in the control group(P<0.05),but the expression of ApoE4 type was significantly higher(P<0.05).The rate of ApoE2 type in the atrial bibrillation group was significantly lower and the rate of ApoE4 type was significantly higher than that in the atrial arrhythmia group(P<0.05).Conclusion The gene expression polymorphism of ApoE gene is associated with atrial arrhythmia and,ApoE4 may be a sensitive phenotype leading to atrial arrhythmia.

关 键 词：房性心律失常 载脂蛋白E 基因 多态性 炎症 心肌重构 

分 类 号：R541.75[医药卫生—心血管疾病]