川崎病患儿血清炎症因子、BNP、h-FABP水平变化及其与冠状动脉损伤的关系  

Changes of serum inflammatory factors,brain natriuretic peptide,and H-FABP levels in children with Kawasaki disease and their relationship with coronary artery damage

作　　者：陈琳 梁彩文 龙丽娜 CHEN Lin;LIANG Cai-wen;LONG Li-na(Department of Pediatrics,Guangzhou Zengcheng District People's Hospital,Guangzhou 511300,Guangdong,CHINA)

机构地区：[1]广州市增城区人民医院儿科,广东广州511300

出　　处：《海南医学》2021年第15期1938-1941,共4页Hainan Medical Journal

摘　　要：目的探讨川崎病患儿血清炎症因子、血清脑利钠肽(BNP)、心型脂肪酸结合蛋白(h-FABP)水平的变化及其与冠状动脉损伤的关系。方法选择2017年11月至2019年11月广州市增城区人民医院儿科确诊的30例川崎病患儿作为研究对象(观察组),根据患儿冠状动脉损伤情况分为损伤组17例和无损伤组13例。同期选择来我院体检的健康儿童30例作为对照组。比较各组受检儿童肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介素-17(IL-17)、BNP、h-FABP表达水平,采用Pearson相关性分析法分析TNF-α、CRP、IL-17、BNP、h-FABP与冠状动脉损伤的关系。结果观察组患儿的TNF-α、CRP、IL-17、BNP、h-FABP表达水平分别为(6.79±1.27)pg/mL、(7.88±1.12)mg/L、(8.59±1.21)pg/mL、(241.12±32.46)ng/L、(19.23±2.45)μg/L,明显高于对照组的(3.52±0.97)pg/mL、(2.97±0.91)mg/L、(3.27±0.78)pg/mL、(47.13±10.17)ng/L、(8.13±2.44)μg/L,差异均有统计学意义(P<0.05);损伤组患儿的TNF-α、CRP、IL-17、BNP、h-FABP表达水平分别为(9.36±2.13)pg/mL、(9.12±2.11)mg/L、(12.10±2.89)pg/mL、(298.13±31.12)ng/L、(23.52±3.77)μg/L,明显高于无损伤组的(6.27±1.17)pg/mL、(5.79±1.02)mg/L、(6.21±1.24)pg/mL、(167.54±29.13)ng/L、(14.65±2.11)μg/L,差异均有统计学意义(P<0.05);经Pearson相关性分析结果显示,川崎病患儿血清TNF-α、CRP、IL-17、BNP、h-FABP表达水平与冠状动脉损伤均呈明显正相关(P<0.05)。结论川崎病患儿的TNF-α、CRP、IL-17、BNP、h-FABP表达水平明显升高,且与冠状动脉损伤呈正相关,密切监测上述指标变化有助于川崎病的早期诊断。Objective To investigate the changes of serum inflammatory factors,brain natriuretic peptide(BNP),and heart type fatty acid binding protein(H-FABP)in children with Kawasaki disease and their relationship with coronary artery damage.Methods Thirty children with Kawasaki disease diagnosed in the Department of Pediatrics,Guangzhou Zengcheng District People's Hospital from November 2017 to November 2019 were selected as the research objects(the observation group),and they were divided into injury group(n=17)and non-injury group(n=13).At the same time,30 healthy children who came to our hospital for physical examination were selected as the control group.The levels of tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-17(IL-17),BNP,and H-FABP were compared between the two groups.Pearson correlation analysis was used to analyze the relationship between TNF-α,CRP,IL-17,BNP,H-FABP and coronary artery damage.Results The expression levels of TNF-α,CRP,IL-17,BNP,and h-FABP in the observation group were(6.79±1.27)pg/mL,(7.88±1.12)mg/L,(8.59±1.21)pg/mL,(241.12±32.46)ng/L,(19.23±2.45)μg/L,respectively,significantly higher than(3.52±0.97)pg/mL,(2.97±0.91)mg/L,(3.27±0.78)pg/mL,(47.13±10.17)ng/L,(8.13±2.44)μg/L in the control group(P<0.05).The expression levels of TNF-α,CRP,IL-17,BNP,and h-FABP in the injury group were(9.36±2.13)pg/mL,(9.12±2.11)mg/L,and(12.10±2.89)pg/mL,(298.13±31.12)ng/L,(23.52±3.77)μg/L,respectively,significantly higher than(6.27±1.17)pg/mL,(5.79±1.02)mg/L,(6.21±1.24)pg/mL,(167.54±29.13)ng/L,(14.65±2.11)μg/L of the non-injured group(P<0.05).Pearson cor-relation analysis showed that serum TNF-α,CRP,IL-17,BNP,h-FABP expression levels in children with Kawasaki dis-ease were significantly positively correlated with coronary artery damage(P<0.05).Conclusion The expression levels of TNF-α,CRP,IL-17,BNP,and h-FABP in children with Kawasaki disease are significantly increased,and are posi-tively correlated with coronary artery damage.Close monitoring of the changes in the

关 键 词：川崎病 冠状动脉损伤 白细胞介素-17 肿瘤坏死因子-α C反应蛋白 血清脑利钠肽 心型脂肪酸结合蛋白 

分 类 号：R725.9[医药卫生—儿科]