加味黄连解毒汤治疗慢性荨麻疹血热证的临床研究  

Clinical Study of Modified Huanglian Jiedu Decoction in the Treatment of Chronic Urticaria with BloodHeat Syndrome

作　　者：朱启辉 杨锐彬 徐海波 ZHU Qihui;YANG Ruibin;XU Haibo(Huicheng Longfeng Health Center,Guangdong Huizhou,516000,China;Huizhou Huakang Hospital,Guangdong Huizhou,516000,China)

机构地区：[1]广东省惠州市惠城区龙丰卫生院,广东惠州516000 [2]广东省惠州市华康医院,广东惠州516000

出　　处：《中医药临床杂志》2021年第7期1365-1368,共4页Clinical Journal of Traditional Chinese Medicine

基　　金：惠州市科技计划(医疗卫生)项目(2020Y008)。

摘　　要：目的:探讨加味黄连解毒汤对慢性荨麻疹血热症患者的临床疗效。方法:选择符合标准的慢性荨麻疹血热症患者108例,根据随机数字表法分为观察组(n=54)和对照组(n=54)。对照组予以氯雷他定片治疗,观察组给予加味黄连解毒汤治疗。比较2组患者治疗6个月后疗效、治疗前及治疗6个月后血清免疫因子[白细胞介素-4(IL-4)及干扰素-γ(IFN-γ)及免疫球蛋白E(IgE)]水平及随访半年统计复发情况。结果:与对照组治疗总有效率相比,观察组高,差异有统计学意义(P<0.05);治疗后,2组IL-4、IgE水平降低,IFN-γ水平升高,观察组IL-4、IgE水平低于对照组,IFN-γ高于对照组,差异有统计学意义(P<0.05);观察组复发率略低于对照组,差异无统计学意义(P>0.05)。结论:加味黄连解毒汤治疗慢性荨麻疹血热证患者疗效确切,可有效调节免疫血清因子水平,改善临床症状,控制复发率。Objective To investigate the clinical effect of Jiawei Huanglian Jiedu Decoction on chronic urticaria with blood heat syndrome.Methods from February 2020 to September 2020,108 patients with chronic urticaria and blood fever in our hospital were selected as the research objects and randomly divided into observation group(n=54)and control group(n=54).The control group was treated with Loratadine Tablets,and the observation group was given Jiawei Huanglian Jiedu decoction.The curative effect after 4 weeks of treatment,the levels of serum immune factors(IL-4,IFN-γand IgE)were compared between the two groups.Results compared with the control group,the total effective rate of the observation group was higher,the difference was statistically significant(P<0.05);after treatment,the levels of IL-4 and IgE in the two groups were decreased,the level of IFN-γwas increased,the level of IL-4 and IgE in the observation group was lower than that in the control group,and IFN-γwas higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion Jiawei Huanglian Jiedu decoction is effective in the treatment of chronic urticaria with blood heat syndrome,which can effectively regulate the level of immune serum factors and improve the clinical symptoms.

关 键 词：慢性荨麻疹 血热证 加味黄连解毒汤 氯雷他定片 

分 类 号：R275.1[医药卫生—中医皮科]