过渡金属催化不饱和烃与有机金属试剂及CO_(2)的串联羧化反应研究进展  

Recent Advance of Transition-Metal-Catalyzed Tandem Carboxyla tion Reaction of Unsaturated Hydrocarbons with Organometallic Reagents and CO_(2)

作　　者：易雅平 杭炜 席婵娟[1,2] Yi Yaping;Hang Wei;Xi Chanjuan(MOE Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology,Department of Chemistry,Tsinghua University,Beijing 100084;State Key Laboratory of Elemento-organic Chemistry,Nankai University,Tianjin 300071)

机构地区：[1]清华大学化学系生命有机磷化学及化学生物学教育部重点实验室,北京1000842 [2]南开大学元素有机化学国家重点实验室,天津300071

出　　处：《有机化学》2021年第1期80-93,共14页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21871163,91645120,21472106)资助项目。

摘　　要：二氧化碳(CO_(2))作为一碳合成子具有储量丰富、无毒无污染、绿色清洁等优点,因此在有机化学领域使用CO_(2)作为一碳合成子反应一直以来受到广泛的关注.过渡金属催化不饱和烃与CO_(2)反应合成羧酸是CO_(2)作为一碳合成子的重要应用之一,这类反应可以通过串联羧化的策略实现,过渡金属催化不饱和烃先与有机金属试剂反应在原位生成新的有机金属试剂,之后再与CO_(2)完成羧化.常用的有机金属试剂如格氏试剂、有机锌试剂和有机铝试剂均能够完成这类反应.根据不饱和烃的类别,并根据羧化反应的类型介绍过渡金属催化不饱和烃与有机金属试剂及CO_(2)的串联羧化反应.Carbon dioxide(CO_(2)),as a one-carbon synthon,has many advantages such as abundant,non-toxic,clean and so on.So the reactions using CO_(2)as a one-carbon synthon have been widely concerned in organic chemistry.Transition-metal-catalyzed reaction of unsaturated hydrocarbons with CO_(2)to produce carboxylic acid is one of the most commonly-used meth-od to convert CO_(2),and organometallic reagents can be added to the reaction as reducing agent.This kind of reaction can be realized by the strategy of tandem reaction.In the reaction,the unsaturated hydrocarbons react with transition-metal catalysts and organometallic reagents to generate new organometallic reagents in situ first,and then complete carboxylation with CO_(2).Common organometallic reagents such as organozinc reagents,Grignard reagents,and organoaluminum reagents can all achieve this kind of carboxylation reaction.In this review,reactions are divided according to the type of unsaturated hydrocar-bons,and each type can also be divided into hydrocarboxylation and carbocarboxylation.This review would introduce reaction according to this classification.

关 键 词：二氧化碳 不饱和烃 羧化反应 过渡金属催化 有机金属试剂 

分 类 号：X701[环境科学与工程—环境工程] O621.251[理学—有机化学]