肝复乐片联合恩替卡韦对乙型肝炎后肝硬化患者Child-pugh的评分及血清AFP水平变化的影响  

Effect of Ganfule Tablets Combined with Entecavir on Child-pugh Score and Serum AFP Level in Patients with Liver Cirrhosis after Hepatitis B

作　　者：陈兴 刘伟锋 CHEN Xing;LIU Weifeng(Department of Infectious Diseases,Yangjiang Public Health Hospital,Yangjiang,Guangdong Province,529500 China)

机构地区：[1]阳江市公共卫生医院感染科,广东阳江529500

出　　处：《中外医疗》2021年第17期84-86,共3页China & Foreign Medical Treatment

摘　　要：目的对乙型肝炎后肝硬化患者采用肝复乐片联合恩替卡韦治疗后的Child-pugh的评分及血清AFP水平改善效果进行分析。方法方便选取该院在2018年1月—2020年1月期间收治的乙型肝炎后肝硬化患者80例作为该次研究的主要对象,将其随机分为常规组和观察组,分别给予恩替卡韦治疗(n=40)联合肝复乐片治疗(n=40),对比分析两种治疗方案对患者Child-pugh的评分及血清AFP水平变化的影响。结果观察组治疗总有效率(95.00%)大于常规组治疗总有效率(80.00%),差异有统计学意义(χ^(2)=4.114,P=0.043),且观察组治疗后的Child-pugh的评分、肝功能及血清AFP水平均相比常规组改善效果较为明显,经对比组间差异有统计学意义(P<0.05)。结论肝复乐片联合恩替卡韦治疗乙型肝炎后肝硬化患者后对其Child-pugh的评分及血清AFP水平改善效果明显,可进行临床推广及采纳。Objective To analyze the Child-pugh score and the improvement effect of serum AFP levels in patients with liver cirrhosis after hepatitis B treated with Ganfule tablets combined with entecavir.Methods Eighty patients with post-hepatitis B cirrhosis admitted to the hospital between January 2018 and January 2020 were conveniently selected as the main subjects of this study.They were randomly divided into the routine group and the observation group,and they were given entecavir treatment(n=40)combined treatment with Ganfule Tablets(n=40),and compared and analyzed the effects of the two treatments on the Child-pugh score and changes in serum AFP levels.Results The total effective rate of treatment in the observation group(95.00%)was higher than the total effective rate of treatment in the routine group(80.00%),the difference was statistically significant(χ^(2)=4.114,P=0.043),and the Child-pugh score,liver function and serum AFP level of the observation group after treatment compared with the routine group,the improvement effect was more obvious,and the difference between the groups was statistically significant(P<0.05).Conclusion Ganfule tablets combined with entecavir has a significant improvement in Child-pugh scores and serum AFP levels in patients with liver cirrhosis after hepatitis B,and can be promoted and adopted clinically.

关 键 词：乙型肝炎后肝硬化 肝复乐片 恩替卡韦 CHILD-PUGH评分 血清AFP水平 治疗总有效率 

分 类 号：R512.62[医药卫生—内科学] R575.2[医药卫生—临床医学]