5'UTR在基因表达调控中的研究进展  

Research Progress of 5'UTR on the Gene Expression Regulation

作　　者：杜芳芳 马骏杰 杨泽伟 赵雪莲 刘东宇 杨秀芹[1] DU Fangfang;MA Junjie;YANG Zewei;ZHAO Xuelian;LIU Dongyu;YANG Xiuqin(College of Animal Science and Technology,Northeast Agricultural University,Heilongjiang Harbin 150030,China)

机构地区：[1]东北农业大学动物科学技术学院,黑龙江哈尔滨150030

出　　处：《中国畜牧杂志》2021年第8期60-67,共8页Chinese Journal of Animal Science

基　　金：国家自然科学基金资助项目(31741114)。

摘　　要：5'非翻译区(5'Untranslated Region,5'UTR)在基因表达调控中发挥重要作用,其不仅在翻译水平调控基因表达,还参与真核基因转录、转录后加工、成熟RNA运输等水平的调控。5'UTR介导的基因表达与自身存在的相关调控元件有关,主要包括内部核糖体进入位点、5'UTR二级结构、上游开放阅读框、上游起始密码子以及5'UTR内含子等元件,5'UTR异常可引起基因表达异常并引发疾病。本文综述了5'UTR调控基因表达的研究进展,以期为今后5'UTR的作用机制及相关疾病的诊断与治疗提供新的方向和理论依据。The 5'untranslated region(5'UTR)plays an important role in the regulation of gene expression.It not only regulates gene expression at the translation level,but also participates in the regulation of eukaryotic gene transcriptional,post-transcriptional,mature RNA transported and translational levels.Therefore,its abnormality can cause abnormal gene expression and eventually lead to disease.5'UTR mediated gene expression is related to its regulatory elements,including internal ribosome entry site,5'UTR secondary structure,upstream open reading frame,upstream initiation codon and 5'UTR introns and other elements.This article reviews the research progress on the 5'UTR regulation of gene expression,to provide a new direction and theoretical basis for the future 5'UTR active mechanism and the diagnosis and treatment of related diseases.

关 键 词：5'UTR 内部核糖体进入位点 上游开放阅读框 上游起始密码子 二级结构 5'UTR内含子 

分 类 号：S813.1[农业科学—畜牧学]