可降解镁金属在骨科中的应用  

Application of degradable magnesium metal in orthopaedics

作　　者：李少鹏 陈豪杰 杨帆[2,3] 马胜利[2] 刘家河 刘保一 Li Shaopeng;Chen Haojie;Yang Fart;Ma Shengli;Liu Jiahe;Liu Baoyi(Dalian Medical University,Dalian Liaoning,116044;Department of Osteoarthritis,Zhongshan Hospital,Dalian University,Dalian Liaoning,116001;Dalian University of Technology,Dalian Liaoning,116024,China)

机构地区：[1]大连医科大学,辽宁大连116044 [2]大连大学附属中山医院,辽宁大连116001 [3]大连理工大学,辽宁大连116024

出　　处：《生物骨科材料与临床研究》2021年第4期92-96,共5页Orthopaedic Biomechanics Materials and Clinical Study

基　　金：中国博士后科学基金面上资助项目(2017M621116);大连市高层次人才创新支持计划――“科技之星”项目(2017RQ154)。

摘　　要：近年来,以可降解镁金属为主的高分子生物材料在医学领域备受瞩目,镁是人体必需的微量元素,它具有与人骨相近的密度和弹性模量、良好的生物相容性及生物可降解等特性,有望成为新一代骨科内固定高分子材料。目前,已有部分镁金属研究在临床治疗中成功实施,但仍未广泛应用,仍需要大量的实验数据及临床研究的支持。本文将通过介绍镁的生物学特性及作为骨植入材料的研究进展,对镁金属在临床上应用的优势与存在的不足进行分析,以及其作为医用可降解高分子生物材料的未来发展进行综述。In recent years,polymer biomaterials dominated by degradable magnesium metals have attracted much attention in the field of medicine.Magnesium is a necessary trace element in human body.It has the characteristics of density and elastic modulus close to human bone,good biocompatibility and biodegradability,and is expected to become a new generation of orthopedic internal fixation polymer materials.At present,some magnesium metal research has been successfully implemented in clinical treatment,but it has not yet been widely used and a large amount of experimental data and clinical research are still needed.This paper will introduce the biological characteristics of magnesium and the research progress of magnesium as bone implant materials,analyze the advantages and disadvantages of magnesium in clinical application,and summarize its future development as medical degradable polymer biomaterials.

关 键 词：镁金属 可降解生物材料 生物相容性 

分 类 号：R318[医药卫生—生物医学工程]