Dysphagia,reflux and related sequelae due to altered physiology in scleroderma  

作　　者：Anusri Kadakuntla Ankit Juneja Samantha Sattler Anusha Agarwal Drishti Panse Nardin Zakhary Anusha Pasumarthi Lee Shapiro Micheal Tadros 

机构地区：[1]Albany Medical College,Albany,NY 12208,United States [2]Department of Dentistry,Ministry of Health,Alexandria 21500,Egypt [3]Division of Rheumatology,Albany Medical Center,Albany,NY 12208,United States [4]Division of Gastroenterology,Albany Medical Center,Albany,NY 12208,United States

出　　处：《World Journal of Gastroenterology》2021年第31期5201-5218,共18页世界胃肠病学杂志（英文版）

摘　　要：Systemic sclerosis is a connective tissue disease that presents with significant gastrointestinal involvement,commonly in the esophagus.Dysphagia is a common clinical manifestation of systemic sclerosis and is strongly related to esophageal dysmotility.However,there are multiple other contributing factors in each step in the physiology of swallowing that may contribute to development of severe dysphagia.The oral phase of swallowing may be disrupted by poor mastication due to microstomia and poor dentition,as well as by xerostomia.In the pharyngeal phase of swallowing,pharyngeal muscle weakness due to concurrent myositis or cricopharyngeal muscle tightening due to acid reflux can cause disturbance.The esophageal phase of swallowing is most commonly disturbed by decreased peristalsis and esophageal dysmotility.However,it can also be affected by obstruction from chronic reflux changes,pill-induced esophagitis,or Candida esophagitis.Other contributing factors to dysphagia include difficulties in food preparation and gastroparesis.Understanding the anatomy and physiology of swallowing and evaluating systemic sclerosis patients presenting with dysphagia for disturbances in each step can allow for development of better treatment plans to improve dysphagia and overall quality of life.

关 键 词：Systemic sclerosis Esophageal motility disorders DEGLUTITION Deglutition disorders Gastroesophageal reflux ESOPHAGITIS 

分 类 号：R593.25[医药卫生—内科学]