间断重复静脉注射左西孟旦治疗老年扩张型心肌病患者的效果及对免疫功能的影响  

Effect of intermittent repeated intravenous injection of levosimendan in the treatment of elderly patients with dilated cardiomyopathy and its influence on immune function

作　　者：黄帅 晋兴震 李正 王晔 HUANG Shuai;JIN Xingzhen;LI Zheng;WANG Ye(Cardiology Department,People's Hospital of Yuncheng County,Heze 274700;Critical Medicine Department,People's Hospital of Yuncheng County,Heze 274700;Cardiology Department,the First Affiliated Hospital of Shandong First Medical University,Jinan 250014,China)

机构地区：[1]郓城县人民医院心内科,山东菏泽274700 [2]郓城县人民医院重症医学科,山东菏泽274700 [3]山东第一医科大学第一附属医院心内科,山东济南250014

出　　处：《临床医学研究与实践》2021年第23期67-69,73,共4页Clinical Research and Practice

摘　　要：目的探究间断重复静脉注射左西孟旦治疗老年扩张型心肌病(DCM)患者的效果及对免疫功能的影响。方法抽选本院2018年1月至2019年1月收治的120例老年DCM患者为研究对象,随机将其分为对照组与观察组,每组60例。对照组施以常规疗法,观察组在对照组基础上加用左西孟旦注射液间断重复静脉注射。比较两组患者治疗前、后的B型钠尿肽(BNP)水平、心率、收缩压、舒张压、C反应蛋白(CRP)、心肌肌钙蛋白I(cTnI)水平、T淋巴细胞亚群及治疗效果。结果治疗后,观察组患者的BNP水平及心率、收缩压、舒张压显著低于对照组,差异具有统计学意义(P<0.05)。治疗后,两组患者的CRP、cTnI水平均较治疗前降低,且观察组显著低于对照组(P<0.05)。治疗后,观察组患者的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)显著高于对照组,差异具有统计学意义(P<0.05)。观察组患者的治疗总有效率显著高于对照组,差异具有统计学意义(P<0.05)。结论间断重复静脉注射左西孟旦可有效改善老年DCM患者的心功能指标,降低BNP水平,提升其机体免疫功能,值得在临床实践中进一步推广应用。Objective To investigate the effect of intermittent repeated intravenous injection of levosimendan in the treatment of elderly patients with dilated cardiomyopathy(DCM)and its influence on immune function.Methods A total of 120 elderly patients with DCM admitted in our hospital from January 2018 to January 2019 were selected as the study objects and randomly divided into control group and observation group,with 60 cases in each group.The control group was treated with conventional therapy,and the observation group was treated with intermittent repeated intravenous injection of levosimendan injection on the basis of the control group.The level of B-type naturetic peptide(BNP),heart rate,systolic pressure,diastolic pressure,C-reactive protein(CRP),myocardial troponin I(cTnI)levels,T lymphocyte subsets before and after treatment and the treatment effect were compared between the two groups.Results After treatment,BNP level,heart rate,systolic pressure and diastolic pressure in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of CRP and cTnI in the two groups were lower than those before treatment,and those in the observation group were significantly lower than the control group(P<0.05).After treatment,the CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the observation group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The intermittent repeated intravenous injection of levosimendan can effectively improve the indexes of cardiac function,reduce BNP level,and elevate bodies'immune function in elderly patients with DCM,which is worthy of further promotion and application in clinical practice.

关 键 词：左西孟旦 扩张型心肌病 免疫功能 

分 类 号：R542.2[医药卫生—心血管疾病]