基于加权TOPSIS法的急性胰腺炎患者抗菌药物应用合理性评价  

Evaluation on Application Rationality of Antibiotics in Patients with Acute Pancreatitis Based on Weighted TOPSIS Method

作　　者：杨万枝[1] 胡章海 解雪峰[2] 吕雄文[2] YANG Wanzhi;HU Zhanghai;XIE Xuefeng;LYU Xiongwen(Dept.of Pharmacy,Anqing First People’s Hospital of Anhui Medical University/Anqing First People’s Hospital of Anhui Province,Anhui Anqing 246003,China;School of Pharmacy,Anhui Medical University,Anhui Hefei 230032,China)

机构地区：[1]安徽医科大学附属安庆第一人民医院/安庆市第一人民医院药学部,安徽安庆246003 [2]安徽医科大学药学院,安徽合肥230032

出　　处：《中国医院用药评价与分析》2021年第7期853-857,共5页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：安徽省高校优秀青年人才支持计划项目(No.gxyq2018006)。

摘　　要：目的:建立急性胰腺炎(acute pancreatitis,AP)患者抗菌药物合理应用评价细则,评估AP患者抗菌药物临床应用的合理性。方法:以《抗菌药物临床应用指导原则(2015年版)》《中国急性胰腺炎诊治指南(2019,沈阳)》《碳青霉烯类抗菌药物临床应用专家共识》和《碳青霉烯类抗菌药物临床应用评价细则》等技术性文件为依据,并根据每种抗菌药物的药品说明书,制定AP患者抗菌药物临床应用合理性评价细则,对2019年1月至2020年12月安庆市第一人民医院(以下简称“该院”)225例使用抗菌药物的AP患者采用加权逼近理想解排序法(technique for order preference by similarity to solution,TOPSIS)进行用药合理性评价,计数各病例与理想解的相对接近度(Ci)。结果:AP患者抗菌药物的不合理应用主要集中在抗菌药物选择不合理、用法与用量不合理以及使用疗程不合理等方面。225例AP患者中,Ci为100%的有53例(占23.56%),80%≤Ci<100%的有4例(占1.78%),60%≤Ci<80%的有141例(占62.67%),Ci<60%的有27例(占12.00%)。结论:基于加权TOPSIS法对AP患者抗菌药物应用进行评价发现,该院AP患者抗菌药物的使用情况基本合理,但仍存在药物选择、用法与用量以及使用疗程等方面不合理的问题。OBJECTIVE:To establish the evaluation rules for the application rationality of antibiotics in patients with acute pancreatitis(AP),so as to evaluate the rationality of clinical practice of antibiotics in patients with AP.METHODS:Based on technical documents such as Guidelines for the Clinical Application of Antibiotics(2015 Edition),Guidelines for the Diagnosis and Treatment of Acute Pancreatitis in China(2019,Shenyang),Expert Consensus on Clinical Application of Carbapenems and Detailed Rules for the Evaluation of the Clinical Application of Carbapenems,and according to the drug instructions of each antibiotics,the evaluation rules of clinical application rationality of antibiotics for patients with AP were formulated.The weighted technique for order preference by similarity to solution(TOPSIS)method was used to evaluate the application rationality of antibiotics in 225 patients with AP from Anqing First People’s Hospital of Anhui Province(hereinafter referred to as the“hospital”)from Jan.2019 to Dec.2020.The relative closeness(Ci)of each case to the ideal solution was counted.RESULTS:The irrational application of antibiotics in patients with AP mainly focused on the improper selection of antibiotics,irrational usage and dosage,and improper treatment course.Among the 225 patients with AP,53 cases(23.56%)had Ci of 100%,4 cases(1.78%)had Ci of 80%-<100%,141 cases(62.67%)had Ci of 60%-<80%,and 27 cases(12.00%)had Ci<60%.CONCLUSIONS:The weighted TOPSIS method is used to evaluate the application of antibiotics in patients with AP,and it is found that the application of antibiotics in patients with AP in the hospital is basically rational,yet there are still irrational problems in drug selection,usage and dosage,and treatment course.

关 键 词：加权TOPSIS法 急性胰腺炎 抗菌药物 合理性评价 

分 类 号：R978.1[医药卫生—药品]