注射用复合辅酶临床应用与重点监控的必要性分析  

Necessity of Clinical Application and Key Monitoring of Coenzyme Complex for Injection

作　　者：杜春辉 牟劲松 朱红 赵艳玲 刘峰群 DU Chunhui;MOU Jinsong;ZHU Hong;ZHAO Yanling;LIU Fengqun(Dept.of Pharmacy,the Fifth Medical Center of Chinese PLA General Hospital,Beijing 100039,China;Critical Care Center,the Fifth Medical Center of Chinese PLA General Hospital,Beijing 100039,China)

机构地区：[1]中国人民解放军总医院第五医学中心药学部,北京100039 [2]中国人民解放军总医院第五医学中心重症医学中心,北京100039

出　　处：《中国医院用药评价与分析》2021年第7期865-866,871,共3页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：军队生物安全建设计划(No.A3704041901-09)。

摘　　要：目的:了解某传染病专科医院(以下简称“该院”)注射用复合辅酶的使用情况,探讨开展辅助用药重点监控的必要性。方法:调取2019—2020年该医疗机构使用过注射用复合辅酶的出院病例共2065例,随机抽取其中300例(占比约15%)进行点评,对患者的科室分布、适应证、用法与用量、禁忌证、配伍禁忌和辅助用药联合应用品种数进行统计分析。结果:注射用复合辅酶在该医疗机构使用广泛,300例患者中,有109例存在不合理用药(占36.33%),其中97例为肝病辅助用药联合应用过多;存在配伍禁忌的处方有18种,疗程过长(>30 d)的患者6例,存在禁忌证的患者2例。结论:注射用复合辅酶作为肝病辅助用药存在较多不合理使用情况,有必要加强监控。OBJECTIVE:To investigate the application of coenzyme complex for injection in an infectious disease hospital(hereinafter referred to as“this hospital”),and to discuss the necessity of key monitoring of adjuvant drugs.METHODS:A total of 2065 discharged patients who received coenzyme complex for injection in this hospital from 2019 to 2020 were selected,among which 300 cases(15%)were randomly selected for review.Statistical analysis was performed on patients’department distribution,indications,usage and dosage,contraindications,compatibility contraindications and the number of combined application of adjuvant drugs.RESULTS:Coenzyme complex for injection was widely used in the medical institution.Among the 300 patients,109 cases had irrational drug application(36.33%),among which 97 cases were off-label application of adjuvant drugs for liver disease.18 kinds of incompatibility contraindication,6 cases of off-label long treatment course(>30 d),and 2 cases of contraindication.CONCLUSIONS:There are many irrational application of coenzyme complex for injection as adjuvant drugs for liver disease,and it is necessary to strengthen the monitoring.

关 键 词：注射用复合辅酶 辅助用药 专项点评 重点监控 

分 类 号：R977[医药卫生—药品]