小而密低密度脂蛋白胆固醇与冠心病的相关性分析  

Analysis of the correlation between small and dense low density lipoprotein cholesterol and coronary heart disease

作　　者：陈桂金[1] 万友利 CHEN Guijin;WAN Youli(Department of Clinical Laboratory,Changzhou Seventh People′s Hospital,Changzhou,Jiangsu 213011,China;Department of Clinical Laboratory,Changzhou First People′s Hospital,Changzhou,Jiangsu 213004,China)

机构地区：[1]江苏省常州市第七人民医院检验科,江苏常州213011 [2]江苏省常州市第一人民医院检验科,江苏常州213004

出　　处：《国际检验医学杂志》2021年第16期1925-1928,1934,共5页International Journal of Laboratory Medicine

基　　金：江苏省自然科学基金项目(BK20171692)。

摘　　要：目的研究冠心病与小而密低密度脂蛋白胆固醇(sdLDL-L)的相关性。方法选取常州市第七人民医院2016年12月至2019年12月收治的185例冠心病患者作为病例组,根据冠状动脉(简称冠脉)不同病变支数将其分为单支冠脉病变122例,双支冠脉病变36例,3支冠脉病变27例;根据冠脉不同狭窄程度将其分为狭窄<50%的97例,50%≤狭窄<75%的54例,狭窄≥75%的34例;另选取同期常州市第七人民医院150例健康体检者作为对照组。入组研究对象分别于不同时间抽取血样后进行高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、sdLDL-C水平检测,并计算sdLDL-C/LDL-C。观察不同研究对象血清学指标检测结果的变化情况,分析冠心病不同病变程度与各项指标间的相关性。结果病例组患者血清HDL-C、LDL-C水平均低于对照组,而血清sdLDL-C水平和sdLDL-C/LDL-C均高于对照组,差异均有统计学意义(P<0.05)。病例组按冠脉病变支数分组:LDL-C水平随冠脉病变支数间变化差异无统计学意义(P>0.05),HDL-C水平随冠脉病变支数增加而依次降低,sdLDL-C水平、sdLDL-C/LDL-C随冠脉病变支数增加而依次递增,差异均有统计学意义(P<0.05);3支冠脉病变患者HDL-C、sdLDL-C水平、sdLDL-C/LDL-C与对照组和单支冠脉病变患者比较,差异均有统计学意义(P<0.05),双支冠脉病变患者HDL-C、sdLDL-C水平与对照组比较,差异均有统计学意义(P<0.05)。病例组按冠脉不同狭窄程度分组:LDL-C水平随冠脉狭窄程度变化差异无统计学意义(P>0.05),HDL-C水平随冠脉狭窄程度增加而依次降低,sdLDL-C水平、sdLDL-C/LDL-C随冠脉狭窄程度增加而依次递增,差异均有统计学意义(P<0.05);冠脉狭窄≥75%的患者HDL-C、sdLDL-C水平、sdLDL-C/LDL-C与对照组和冠脉狭窄<50%的患者比较,差异均有统计学意义(P<0.05),50%≤冠脉狭窄<75%的患者HDL-C水平、sdLDL-C/LDL-C与对照组比较,差异均有统计学意义(P<0.05)。冠�Objective To study the correlation between coronary heart disease and small and dense low density lipoprotein cholesterol(sdLDL-C).Methods A total of 185 patients with coronary heart disease admitted to Changzhou Seventh People′s Hospital from December 2016 to December 2019 were selected as the case group.According to the number of lesion branches of coronary artery,they were divided into 122 cases of single coronary artery lesion,36 cases of double coronary artery lesion and 27 cases of three coronary artery lesion.According to the different degree of stenosis,they were divided into 97 cases of stenosis<50%,54 cases of 50%≤stenosis<75%,and 34 cases of stenosis≥75%.In addition,150 healthy people in Changzhou Seventh People′s Hospital were selected as the control group.High density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)and sdLDL-C were detected after blood samples were taken at different times,and the sdLDL-C/LDL-C value was calculated.The changes of serological indexes of different subjects were observed,and the correlation between different pathological degrees of coronary heart disease and various indexes were analyzed.Results The levels of serum HDL-C and LDL-C in the case group were lower than those in the control group,while the level of serum sdLDL-C and sdLDL-C/LDL-C were higher than those in the control group,and the differences were statistically significant(P<0.05).According to the number of lesion branches in the case group:there was no significant difference in the change of LDL-C level with the change of number of lesion branches of coronary artery(P>0.05),HDL-C level decreased with the increase of lesion branches of coronary artery,sdLDL-C level and sdLDL-C/LDL-C increased with the increase of lesion branches of coronary artery,and the differences were statistically significant(P<0.05).There were significant differences in levels of HDL-C,sdLDL-C,sdLDL-C/LDL-C between patients with three coronary artery lesions and the control group and patients with single

关 键 词：冠心病 小而密低密度脂蛋白胆固醇 高密度脂蛋白胆固醇 低密度脂蛋白胆固醇 

分 类 号：R541.4[医药卫生—心血管疾病]