异丙嗪联合间苯三酚在妊娠合并肾绞痛急诊处理中的安全性及有效性探讨  

Safety and effectiveness of promethazine combined with phloroglucinol in emergency treatment of renal colic during pregnancy

作　　者：张勇科[1] 谭俊斌 ZHANG Yong-ke;TAN Jun-bin(Department of Urology Surgery,Gaoming District People’s Hospital,Foshan 528500,China)

机构地区：[1]佛山市高明区人民医院泌尿外科,528500 [2]佛山市高明区荷城街道月明社区卫生服务站,528500

出　　处：《中国实用医药》2021年第23期40-43,共4页China Practical Medicine

基　　金：广东省佛山市科技计划项目(项目编号:2018AB000814)。

摘　　要：目的探讨异丙嗪联合间苯三酚在妊娠合并肾绞痛急诊处理中的安全性及有效性。方法120例妊娠合并肾绞痛孕妇作为研究对象,按照抽签法分为A组、B组、C组和D组,各30例。急诊处理时,A组患者给予间苯三酚联合异丙嗪治疗,B组患者给予山莨菪碱联合异丙嗪治疗,C组患者给予间苯三酚治疗,D组患者给予山莨菪碱治疗。比较四组视觉模拟评分法(VAS)评分,疼痛显效时长与72 h内疼痛再发率,药物不良反应发生情况。结果用药1 h后,四组VAS评分均较用药前显著降低,且四组VAS评分比较差异有统计学意义(P<0.05);A组VAS评分(1.06±0.52)分明显低于B组的(1.59±0.74)分、C组的(2.57±1.02)分和D组的(2.84±1.24)分,B组VAS评分明显低于C组和D组,差异有统计学意义(P<0.05);C组和D组VAS评分比较差异无统计学意义(P>0.05)。四组疼痛显效时长与72 h内疼痛再发率比较差异有统计学意义(P<0.05);A组疼痛显效时长(19.74±5.69)min明显短于B组的(23.72±6.88)min、C组的(26.38±7.65)min和D组的(28.71±7.18)min,B组疼痛显效时长明显短于D组,差异具有统计学意义(P<0.05)。A组和B组72 h内疼痛再发率分别为6.67%、16.67%,均明显低于D组的40.00%,差异具有统计学意义(P<0.05)。四组恶心呕吐、嗜睡、心慌、皮疹发生率比较差异均无统计学意义(P>0.05)。结论异丙嗪联合间苯三酚在妊娠合并肾绞痛急诊处理中疗效显著,能有效缓解疼痛,且镇痛持续时间较长,安全性良好,具有较高的临床应用价值。Objective To discuss the safety and effectiveness of promethazine combined with phloroglucinol in emergency treatment of renal colic during pregnancy.Methods A total of 120 maternal women with renal colic during pregnancy as study subjects were divided into group A,group B,group C and group D according to lottery method,with 30 cases in each group.During emergency treatment,group A was treated with promethazine and phloroglucinol,group B was treated with anisodamine and promethazine,group C was treated with phloroglucinol,and group D was treated with anisodamine.The visual analogue scale(VAS)score,pain effective time,recurrence rate of pain within 72 h,and the incidence of adverse drug reactions of the four groups were compared.Results 1 h after medication,the VAS score of the four groups were significantly lower than those before medication,and there was no statistically significant difference in VAS score among the four groups(P<0.05).The VAS score(1.06±0.52)points of group A was obviously lower than(1.59±0.74)points of group B,(2.57±1.02)points of group C and(2.84±1.24)points of group D,and group B was obviously lower than group C and group D.All the difference was statistically significant(P<0.05).There was no statistically significant difference in VAS score between group C and group D(P>0.05).There was statistically significant difference in pain effective time and recurrence rate of pain within 72 h among the four groups(P<0.05).The pain effective time(19.74±5.69)min of group A was obviously shorter than(23.72±6.88)min of group B,(26.38±7.65)min of group C and(28.71±7.18)min of group D,and group B was obviously shorter than group D.All the difference was statistically significant(P<0.05).The recurrence rate of pain within 72 h of group A and group B were 6.67%and 16.67%,which were obviously lower than 40.00%of group D,and the difference was statistically significant(P<0.05).There was no statistically significant difference in incidence of nausea and vomiting,drowsiness,palpitation,skin rash among t

关 键 词：异丙嗪 间苯三酚 妊娠 肾绞痛 

分 类 号：R714.258[医药卫生—妇产科学]