慢性鼻窦炎患者血清ECP、TIgE、TGF-β1水平变化及临床意义  

Changes and clinical significance of serum ECP,TIgE and TGF-β1 levels in patients with chronic sinusitis

作　　者：张雄[1] ZHANG Xiong(Department of Otolaryngology Head and Neck Surgery,Panzhihua Hospital of Integrated Traditional Chinese and Western Medicine,Panzhihua 617000,Sichuan,China)

机构地区：[1]攀枝花市中西医结合医院耳鼻喉头颈外科,四川攀枝花617000

出　　处：《川北医学院学报》2021年第8期999-1002,共4页Journal of North Sichuan Medical College

基　　金：四川省教育厅科研项目(17ZB0240)。

摘　　要：目的:探讨慢性鼻窦炎患者血清嗜酸性粒细胞阳离子蛋白(ECP)、总免疫球蛋白E(TIgE)和转化生长因子β1(TGF-β1)水平变化及临床意义。方法:选取107例行鼻内镜手术治疗的慢性鼻窦炎患者为研究对象,根据术后3个月预后分为复发组(n=23)和未复发组(n=84);比较手术前后及术后3个月不同预后患者血清ECP、TIgE、TGF-β1水平变化。结果:术后1周、4周和12周,慢性鼻窦炎患者的视觉模拟量表评分(VAS评分)和Lund-kennedy内窥镜评分及血清ECP、TIgE和TGF-β1水平均较术前下降(P<0.05);且复发组患者血清ECP、TIgE和TGF-β1水平均高于未复发组(P<0.05)。相关性分析显示,血清ECP、TIgE及TGF-β1水平呈正相关(P<0.05)。ROC曲线分析显示,ECP、TIgE和TGF-β1预测术后复发的AUC值分别为0.707、0.805和0.688。结论:慢性鼻窦炎患者血清ECP、TIgE和TGF-β1水平升高,且与预后密切相关,对预测术后复发具有一定价值。Objective:To explore the changes and clinical significance of serum eosinophil cationic protein(ECP),total immunoglobulin E(TIgE)and transforming growth factorβ1(TGF-β1)levels in patients with chronic sinusitis.Methods:107 patients with chronic sinusitis who underwent endoscopic sinus surgery were selected as the research objects.According to the prognosis of 3 months after operation,they were divided into recurrence group(n=23)and non recurrence group(n=84).The changes of serum ECP,TIgE and TGF-β1 levels in patients with different prognosis before and after operation and 3 months after operation were compared.Results:1,4 and 12 weeks after operation,the VAS and Lund-kennedy scores,levels of serum ECP,TIgE and TGF-β1 were significantly reduced in the observation group(P<0.05).The recurrence group had higher serum ECP,TIgE and TGF-β1 levels than the non recurrence group(P<0.05).Correlation analysis showed that there was a positive correlation between serum ECP,TIgE and TGF-β1 levels(P<0.05).ROC curve analysis showed that the AUC values of ECP,TIgE and TGF-β1 were 0.707,0.805,and 0.688,respectively(P<0.05).Conclusion:The serum ECP,TIgE and TGF-β1 levels in patients with chronic sinusitis is increased,which is closely related to the prognosis,and has a certain value in predicting postoperative recurrence.

关 键 词：慢性鼻窦炎 鼻内镜手术 嗜酸性粒细胞阳离子蛋白 总免疫球蛋白E 转化生长因子β1 

分 类 号：R765.9[医药卫生—耳鼻咽喉科]