伊曲康唑联合萘替芬酮康唑乳膏治疗角化过度型手足癣的疗效及其对皮肤美容度的影响  

Efficacy of itraconazole combined with naftifine hydrochloride and ketoconazole cream in the treatment of hyperkeratotic tinea of hand and foot and its clinical observation on skin beauty

作　　者：林宁宁[1] 林瑞静 王亚斐[1] 徐海丰[1] 杨会君[1] LIN Ning-ning;LIN Rui-jing;WANG Ya-fei;XU Hai-feng;YANG Hui-jun(Department of Dermatology,First Hospital of Qinhuangdao,Qinhuangdao 066000;Department of Physical Examination,Luanping Hospital of Traditional Chinese Medicine,Luanping 068250,Hebei,China)

机构地区：[1]秦皇岛市第一医院皮肤科,河北秦皇岛066000 [2]滦平县中医院体检科,河北滦平068250

出　　处：《川北医学院学报》2021年第8期1024-1028,共5页Journal of North Sichuan Medical College

基　　金：河北省秦皇岛市科学技术研究与发展计划(201805A047)。

摘　　要：目的:探讨伊曲康唑联合萘替芬酮康唑乳膏治疗角化过度型手足癣的疗效及其对皮肤美容度的影响。方法:选取113例过度型手足癣患者分为联合组(n=57)和对照组(n=56)。对照组给予萘替芬酮康唑乳膏涂抹治疗,联合组在外涂萘替芬酮康唑乳膏的基础上联合伊曲康唑口服;比较两组患者的临床疗效、症状评分、治疗依从性、皮肤美容度及复发率。结果:治疗后,联合组总有效率为92.98%,高于对照组的76.78%(P<0.05);治疗后,两组患者各项临床症状评分及总分均较治疗前显著降低(P<0.05),且治疗后联合组与对照组比较,差异存在统计学意义(P<0.05);两组患者皮肤美容度各方面评分及总分均较治疗前降低(P<0.05),且两组间存在统计学差异(P<0.05);联合组患者治疗依从率为96.49%,高于对照组的80.36%(P<0.05);治疗期间,两组患者均未见不良反应发生;随访发现,联合组复发3例(7.69%),对照组复发7例(30.43%),差异有统计学意义(P<0.05)。结论:伊曲康唑联合萘替芬酮康唑乳膏治疗角化过度型手足癣临床疗效较显著,可有效改善患者临床症状,提高皮肤美容度和治疗依从性,复发率较低,安全性高,有一定的临床推广应用价值。Objective:To explore the efficacy of itraconazole combined with naftifine hydrochloride and ketoconazole cream in the treatment of hyperkeratotic tinea of hand and foot and its clinical observation on skin beauty.Methods:A total of 113 patients with hyperkeratotic tinea of hand and foot were selected and divided into combined group(n=57)and control group(n=56).Patients in control group were given naftifine hydrochloride and ketoconazole cream for application treatment,and patients in combined group were combined with itraconazole orally on the basis of external application of naftifine hydrochloride and ketoconazole cream.The clinical efficacy,symptoms scores,treatment compliance,skin beauty and recurrence rate were compared between the two groups.Results:After treatment,the total effective rate of combined group was significantly higher than that of control group(92.98%vs.76.78%,P<0.05).After treatment,the scores of various clinical symptoms and total score of the two groups were significantly reduced compared with those before treatment(P<0.05),and there were significant differences in the scores between combined group and control group after treatment(P<0.05).The scores of all aspects and total score of skin beauty of the two groups were significantly lower than those before treatment(P<0.05),and the scores in combined group were significantly different from those in control group(P<0.05).The treatment compliance rate of patients with 96.49%in combined group was significantly higher than 80.36%in control group(P<0.05).During treatment,there were no occurrence of adverse reactions in the two groups.Follow-up found that there were 3 cases of recurrence in combined group with the recurrence rate of 7.69%,and there were 7 cases of recurrence in control group with the recurrence rate of 30.43%,the difference was statistically significant(P<0.05).Conclusion:Itraconazole combined with naftifine hydrochloride and ketoconazole cream has a significant clinical efficacy in the treatment of hyperkeratotic tinea of hand an

关 键 词：角化过度型手足癣 伊曲康唑 萘替芬酮康唑乳膏 皮肤美容度 疗效 

分 类 号：R756.3[医药卫生—皮肤病学与性病学] R289.6[医药卫生—临床医学]