多环多异戊烯基间苯三酚类天然产物的研究进展  

Research progress of polycyclic polyprenylated acylphloroglucinols natural products

作　　者：赵雪冰 郭翼 王燕燕[1] 张勇慧[2] ZHAO Xue-bing;GUO Yi;WANG Yan-yan;ZHANG Yong-hui(the First College of Clinical Medical Sciencey China Three Gorges University/Yichang Central People's Hospital,Yichang 443003,China;School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]三峡大学第一临床医学院/宜昌市中心人民医院,湖北宜昌443003 [2]华中科技大学同济医学院药学院,湖北武汉430030

出　　处：《中国中药杂志》2021年第12期3076-3086,共11页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(31570361,31270390)。

摘　　要：多环多异戊烯基间苯三酚衍生物(polycyclic polyprenylated acylphloroglucinols,PPAPs)化学结构复杂多变且药理活性广泛,已成为当前天然产物的研究热点之一。特别是其中部分PPAPs,不仅具有新颖的非传统骨架,同时也可能蕴藏了更多未知的活性,对于先导化合物的开发有着重要意义。对近年来分离鉴定的具有非传统骨架类型的PPAPs的结构、来源、生物合成途径以及药理活性进行综述,以期为此类化合物的进一步研究提供参考。Due to their fascinating chemical structures and extensive pharmacological activities, polycyclic polyprenylated acylphloroglucinols(PPAPs) have become one of the current research hotspots of natural products. In particular, some of the PPAPs not only have novel non-traditional skeleton types, but also contain more unknown possible activities, which are of great significance for the development of lead compounds. The structure, source, biosynthetic pathway and pharmacological activities of PPAPs with non-traditio-nal skeleton types isolated and identified in recent years are reviewed, in order to provide references for further research on such compounds.

关 键 词：多环多异戊烯基间苯三酚 非传统骨架 结构 来源 生物合成途径 药理活性 

分 类 号：R284[医药卫生—中药学]