Prediction of mortality among patients with chronic kidney disease:A systematic review  

作　　者：Panupong Hansrivijit Yi-Ju Chen Kriti Lnu Angkawipa Trongtorsak Max M Puthenpura Charat Thongprayoon Tarun Bathini Michael A Mao Wisit Cheungpasitporn 

机构地区：[1]Department of Internal Medicine,UPMC Pinnacle,Harrisburg,PA 17104,United States [2]Department of Internal Medicine,Amita Health Saint Francis Hospital,Evanston,IL 60202,United States [3]Department of Medicine,Drexel University College of Medicine,Philadelphia,PA 19129,United States [4]Division of Nephrology and Hypertension,Department of Medicine,Mayo Clinic,Rochester,MN 55905,United States [5]Department of Internal Medicine,University of Arizona,Tucson,AZ 85721,United States [6]Division of Nephrology and Hypertension,Mayo Clinic,Jacksonville,FL 32224,United States

出　　处：《World Journal of Nephrology》2021年第4期59-75,共17页世界肾病学杂志（英文版）

摘　　要：BACKGROUND Chronic kidney disease(CKD)is a common medical condition that is increasing in prevalence.Existing published evidence has revealed through regression analyses that several clinical characteristics are associated with mortality in CKD patients.However,the predictive accuracies of these risk factors for mortality have not been clearly demonstrated.AIM To demonstrate the accuracy of mortality predictive factors in CKD patients by utilizing the area under the receiver operating characteristic(ROC)curve(AUC)analysis.METHODS We searched Ovid MEDLINE,EMBASE,and the Cochrane Library for eligible articles through January 2021.Studies were included based on the following criteria:(1)Study nature was observational or conference abstract;(2)Study populations involved patients with non-transplant CKD at any CKD stage severity;and(3)Predictive factors for mortality were presented with AUC analysis and its associated 95%confidence interval(CI).AUC of 0.70-0.79 is considered acceptable,0.80-0.89 is considered excellent,and more than 0.90 is considered outstanding.RESULTS Of 1759 citations,a total of 18 studies(n=14579)were included in this systematic review.Eight hundred thirty two patients had non-dialysis CKD,and 13747 patients had dialysis-dependent CKD(2160 patients on hemodialysis,370 patients on peritoneal dialysis,and 11217 patients on non-differentiated dialysis modality).Of 24 mortality predictive factors,none were deemed outstanding for mortality prediction.A total of seven predictive factors[N-terminal pro-brain natriuretic peptide(NT-proBNP),BNP,soluble urokinase plasminogen activator receptor(suPAR),augmentation index,left atrial reservoir strain,C-reactive protein,and systolic pulmonary artery pressure]were identified as excellent.Seventeen predictive factors were in the acceptable range,which we classified into the following subgroups:predictors for the non-dialysis population,echocardiographic factors,comorbidities,and miscellaneous.CONCLUSION Several factors were found to predict mortality in CKD pati

关 键 词：Chronic kidney disease End stage kidney disease End stage renal disease DIALYSIS MORTALITY DEATH PREDICTORS 

分 类 号：R69[医药卫生—泌尿科学]