祛风宣窍、清肺化痰法辅助治疗小儿过敏性鼻炎效果及对Tim-1、ICAM-1、VCAM-1变化的研究  

Study on Changes of Tim-1,ICAM-1 and VCAM-1 in Children with Allergic Rhinitis Treated with Adjunctive Therapy by Expelling Wind and Expelling Orifice and Clearing Lung and Removing Phlegm Method

作　　者：张驰[1] 王革新[1] 王大强[2] 王立新 杜碧丽 ZHANG Chi;WANG Gexin;WANG Daqiang;WANG Lixin;DU Bili(Department of Basic Medicine,Nanyang Medical College,Nanyang 473000,Henan,China;The First Affiliated Hospital of Nanyang Medical College,Nanyang 473000,Henan,China)

机构地区：[1]南阳医学高等专科学校基础医学部,河南南阳473000 [2]南阳医学高等专科学校第一附属医院,河南南阳473000

出　　处：《中华中医药学刊》2021年第7期92-95,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家中医药管理局中医药行业科研项目(2018083039)。

摘　　要：目的研究祛风宣窍、清肺化痰法辅助西医治疗小儿过敏性鼻炎对患儿T细胞免疫球蛋白域黏蛋白域蛋白-1(Tim-1)、细胞间黏附分子-1(ICAM-1)、血管细胞黏附分子-1(VCAM-1)的变化影响。方法选取医院2018年1月—2019年8月收治的小儿过敏性鼻炎患儿84例,采用随机数字法分为两组。对照组给予常规西医对症治疗,观察组给予祛风宣窍、清肺化痰法辅助治疗,分析两组患儿治疗后的临床效果。结果观察组中医证候有效率(90.48%,38/42)高于对照组(73.81%,31/42),差异具有统计学意义(P<0.05)。观察组鼻痒缓解时间(3.56±0.28)d、流涕缓解时间(4.07±0.28)d、鼻塞缓解时间(3.05±0.34)d、打喷嚏缓解时间(3.02±0.30)d短于对照组(P<0.05)。两组治疗前Tim-1、ICAM-1、VCAM-1、白细胞介素水平组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后白细胞介素-12(IL-12)水平高于对照组,Tim-1、ICAM-1、VCAM-1、白细胞介素-5(IL-5)、白细胞介素-17(IL-17)、白细胞介素-23(IL-23)水平低于对照组(P<0.05)。结论祛风宣窍、清肺化痰法辅助西医治疗小儿过敏性鼻炎可减轻炎症反应,调节相关细胞的表达水平,促进症状的缓解。Objective To study the effects of expelling wind and expelling orifice and clearing lung and removing phlegm method on the changes of T cell immunoglobulin domain mucoprotein 1(Tim-1), intercellular adhesion molecule-1(ICAM-1) and vascular cell adhesion molecule-1(VCAM-1) in children with allergic rhinitis. Methods From January 2018 to August 2019, 84 children with allergic rhinitis were randomly divided into two groups. The control group was given routine western medicine symptomatic treatment. The observation group was given expelling wind and expelling orifice and clearing lung and removing phlegm auxiliary treatment, and the clinical effect of the two groups after treatment was analyzed. Results The effective rate of TCM syndrome in the observation group(90.48%,38/42) was higher than that in the control group(73.81%,31/42). The difference was statistically significant(P<0.05). The relief time of nasal itching, runny nose, nasal congestion and sneezing in the observation group was(3.56±0.28)days,(4.07±0.28) days,(3.05±0.34)days and(3.02±0.30)days respectively, which were shorter than those in the control group(P<0.05). The difference of Tim-1, ICAM-1, VCAM-1 and interleukins in two groups was not statistically significant(P>0.05). The level of interleukin-12(IL-12) in the treatment group was higher than that of the control group(P<0.05), and the level of interleukin-12(IL-12) was higher than that in the control group(P<0.05). Conclusion The expelling wind and expelling orifice and clearing lung and removing phlegm method of allergic rhinitis in children can reduce inflammatory reaction, regulate the expressions of related cells and promote the relief of symptoms.

关 键 词：祛风宣窍、清肺化痰法 小儿过敏性鼻炎 T细胞免疫球蛋白域黏蛋白域蛋白-1 炎症反应 

分 类 号：R276.165.21[医药卫生—中医五官科学]