桑菊清解汤治疗痰热蕴肺型慢性阻塞性肺疾病临床疗效及对免疫功能影响  

Effect of Sangju Qingjie Decoction(桑菊清解汤)on Chronic Obstructive Pulmonary Disease with Phlegm-Heat Accumulation and Its Influence on Immune Function

作　　者：黄莹[1] 黄进[1] 董子青[1] 陈少藩[1] 陈剑锋 黄振炎[1] HUANG Ying;HUANG Jin;DONG Ziqing;CHEN Shaofan;CHEN Jianfeng;HUANG Zhenyan(Zhongshan Hospital of Traditional Chinese Medicine,Zhongshan 528400,Guangdong,China)

机构地区：[1]中山市中医院,广东中山528400

出　　处：《中华中医药学刊》2021年第7期184-187,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：广东省中医药管理局科研项目(105182);中山市社会公益科技研究项目(第一批)立项项目(2019B1048)。

摘　　要：目的观察桑菊清解汤治疗痰热蕴肺型慢性阻塞性肺疾病的临床疗效及免疫功能影响。方法选择2017年12月—2018年12月医院收治的慢性阻塞性肺疾病患者60例,依据随机对照法分为两组。对照组30例采用西药常规治疗,包括抗感染、化痰止咳、抗炎及解痉平喘,必要时无创辅助通气。试验组30例在对照组治疗的基础上,口服桑菊清解汤治疗。服法:30 mL/次,3次/d。两组共治疗2周。比较两组动脉血气功能、运动情况以及T淋巴细胞亚群水平,比较中医证候变化及治疗疗效。结果试验组治疗总有效率优于对照组(P<0.05);试验组治疗后咳嗽、咳痰、喘息、便秘和哮鸣音等中医证候积分优于对照组(P<0.05);实验组治疗后血气指标氧分压(PO_(2))、二氧化碳分压(PCO_(2))和6 min步行试验(6MWT)改善幅度优于对照组(P<0.05);试验组治疗后T淋巴细胞亚群CD^(+)_(4)、CD^(+)_(8)和CD^(+)_(4)/CD^(+)_(8)改善幅度优于对照组(P<0.05)。结论桑菊清解汤结合西药常规治疗慢性阻塞性肺疾病痰热蕴肺型疗效确切,可有效改善患者的中医证候和动脉血气指标,调节患者的免疫指标,提高患者的运动能力和肺功能,临床效果显著,值得进一步研究探讨。Objective To observe the clinical efficacy and immune function of Sangju Qingjie Decoction(桑菊清解汤) in the treatment of chronic obstructive pulmonary disease(COPD) of phlegm-heat accumulation type. Methods Sixty patients with COPD in our hospital from December 2017 to December 2018 were selected and randomly divided into two groups. In the control group, 30 patients were treated with western medicine, including anti-infection, resolving phlegm and relieving cough, anti-inflammatory, spasmolysis and relieving asthma and noninvasive auxiliary ventilation if necessary. The treatment group’s 30 patients were treated with Sangju Qingjie Decoction on the basis of the control group, 30 mL/time, 3 times a day. The two groups were treated for 2 weeks. The therapeutic effect, TCM syndrome score, arterial blood gas function, exercise and T lymphocyte subsets were compared between the two groups. Results The treatment group’s total effectiveness was better than that of the control group(P<0.05). In the treatment group after treatment, TCM symptom scores(cough, sputum, breathing, constipation and wheezing sound) were better than those of the control group(P<0.05). After treatment, the improvement of PO2, PCO_(2)and 6 MWT in the treatment group was better than that in the control group(P<0.05). After treatment, CD^(+)_(4) and CD^(+)_(8) of T lymphocyte subsets in the treatment group were better than those in the control group. The improvement of CD^(+)_(4)/CD^(+)_(8) and CD^(+)_(4)/CD^(+)_(8) was better than that of the control group(P<0.05). Conclusion Sangju Qingjie Decoction combined with conventional western medicine in the treatment of chronic obstructive pulmonary disease with phlegm-heat accumulation in lung type has exact curative effect, can effectively improve the patients’ TCM symptoms and arterial blood gas index, regulate the patients’ immune index, and improve the patients’ exercise ability and lung function. The clinical effect is significant and it is worthy of further study and discussion.

关 键 词：桑菊清解汤 慢性阻塞性肺疾病 痰热蕴肺型 疗效 免疫功能 影响 

分 类 号：R259.63[医药卫生—中西医结合]