养金护肺汤对厄洛替尼治疗老年中晚期非小细胞肺癌B细胞、NK细胞的影响  

Effect of Yangjin Hufei Decoction(养金护肺汤)on B Cells and NK Cells in Elderly Non-Small Cell Lung Cancer Patients Treated with Erlotinib at Advanced Stage

作　　者：岳亚丽 徐梦姗 朱其聪[2] 王亚辉[2] YUE Yali;XU Mengshan;ZHU Qicong;WANG Yahui(Hainan Cancer Hospital,Haikou 570100,Hainan,China;928 Hospital of The Joint Service Support Force of The people's Liberation Army,Haikou 570100,Hainan,China)

机构地区：[1]海南省肿瘤医院,海南海口570100 [2]中国人民解放军联勤保障部队第928医院,海南海口570100

出　　处：《中华中医药学刊》2021年第7期235-238,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：海南省卫生基金(琼卫科教[2018]117号)。

摘　　要：目的探讨养金护肺汤对厄洛替尼治疗老年中晚期非小细胞肺癌(NSCLC)患者B细胞、NK细胞的影响。方法选取诊治的老年中晚期NSCLC患者100例,将患者根据数字表格法随机分为对照组与研究组,每组50例,厄洛替尼口服治疗,研究组同时给与养金护肺汤进行治疗,疗程30 d,观察治疗前后B细胞及NK细胞、中医证候积分变化,治疗期间不良反应发生情况,治疗前后体力状况评分(KPS)变化,进行疗效评定。结果 B细胞及NK细胞水平对照组治疗后较治疗前下降(P<0.05),研究组治疗后较治疗前升高(P<0.05),治疗后B细胞及NK细胞水平两组之间比较差异有统计学意义(P<0.05);两组患者中医证候积分主证及次证积分治疗后较治疗前下降(P<0.05),研究组下降幅度大于对照组(P<0.05);两组患者治疗期间不良反应均以皮疹、腹泻为主,其次为恶心呕吐,对照组的发生率分别为30.00%(15/50)、26.00%(13/50)、14.00%(7/50),研究组分别为14.00%(7/50)、12.00%(6/50)、2.00%(1/50),比较差异有统计学意义(P<0.05);两组患者KPS评分治疗后较治疗前升高(P<0.05),研究组升高幅度大于对照组(P<0.05);对照组治疗有效率(ORR)与疾病控制率(DCR)分别为44.00%(22/50)、76.00%(38/50),研究组分别为50.00%(25/50)、82.00%(41/50),比较差异无统计学意义(P>0.05)。结论厄洛替尼治疗老年中晚期非小细胞肺癌患者给与养金护肺汤辅助治疗,有助于改善B细胞、NK细胞功能及临床症状,减轻化疗不良反应,提高KPS评分。Objective To investigate the effect of Yangjin Hufei Decoction(养金护肺汤) on B cells and NK cells in elderly patients treated with erlotinib for advanced stage non-small cell lung cancer(NSCLC). Methods We collected 100 cases of elderly NSCLC patients treated with erlotinib at the advanced stage. The patients were randomly divided into control group and study group according to the number table method, 50 cases in each group. Both groups were treated with erlotinib orally. The study group was also treated with Yangjin Hufei Decoction. The treatment course was 30 d. We observed the changes of B cells, NK cells and TCM syndrome scores before and after treatment. The occurrence of toxic and side effects of drugs and physical condition score(KPS) of patients before and after treatment were observed and the efficacy was evaluated. Results The levels of B cells and NK cells in the control group were decreased after treatment compared with those before treatment(P<0.05). The study group’s levels of B cells and NK cells were higher after treatment than those before treatment(P<0.05). There was a statistically significant difference in the levels of B cells and NK cells between the two groups after treatment(P<0.05). The TCM syndrome integral main syndrome and secondary syndrome integral in the two group were decreased after treatment(P<0.05). The decrease of the study group was greater than that of the control group(P<0.05). The side effects of chemotherapy were mainly skin rash and diarrhea, followed by nausea and vomiting. The incidence rates were 30.00%(15/50), 26.00%(13/50) and 14.00%(7/50) in the control group, and 14.00%(7/50), 12.00%(6/50) and 2.00%(1/50) in the study group. The difference was statistically significant(P<0.05). KPS score in the two groups was increased after treatment compared with that before treatment(P<0.05), and the increase in the study group was greater than that in the control group(P<0.05). The treatment response rate(ORR) and disease control rate(DCR) in the control group were 44.

关 键 词：养金护肺汤 厄洛替尼 老年 中晚期 非小细胞肺癌 B细胞 NK细胞 

分 类 号：R273.342[医药卫生—中西医结合]