肺力咳合剂联合阿奇霉素治疗儿童重症支原体肺炎效果评估  

Effect Evaluation of Feilike Mixture(肺力咳合剂)Combined with Azithromycin in Treatment of Severe Mycoplasma Pneumonia in Children

作　　者：张会欣 贺新建[1] 李红艳[1] 刘蕾[1] 樊艳辉[1] ZHANG Huixin;HE Xinjian;LI Hongyan;LIU Lei;FAN Yanhui(Hebei Children's Hospital,Shijiazhuang 071000,Hebei,China)

机构地区：[1]河北省儿童医院,河北石家庄071000

出　　处：《中华中医药学刊》2021年第7期243-246,I0032,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：河北省医学科学研究重点课题计划(G2018083)。

摘　　要：目的探讨肺力咳合剂联合阿奇霉素治疗儿童重症支原体肺炎的效果。方法选择2018年1月—2019年11月在河北省儿童医院儿科住院治疗的重症支原体肺炎患儿102例,依据随机数字的方法,将全部患儿分为对照组和观察组,每组51例。对照组患儿采用以阿奇霉素为主的治疗方案,观察组患儿在对照组治疗方法基础上给予肺力咳合剂。对比两组的各类症状持续时间(体温升高、气喘、咳嗽、肺部罗音),治疗前后的血清炎性因子水平[C反应蛋白(CRP)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)]、治疗过程中的不良反应情况、治疗效果。结果观察组患儿"体温升高""气喘""咳嗽""肺部罗音"的持续时间均短于对照组患儿(t=2.454,2.422,2.594,2.491,P<0.05)。两组在治疗前的CRP、IL-10、TNF-α数据差异无统计学意义(P>0.05),治疗后两组的CRP、TNF-α均降低,IL-10均增高,观察组的CRP、TNF-α均低于对照组,IL-10高于对照组,差异具有统计学意义(P<0.05)。两组在治疗过程中发生不良反应的人数比例数据差异不具有统计学意义(χ^(2)=0.172,P>0.05)。观察组的治疗效果优于对照组(z=1.864,P<0.05)。患儿在经过治疗后,各类肺部典型B超表现均出现明显改善。结论在重症支原体肺炎患者的治疗过程中,采用阿奇霉素治疗策略的基础上,联合使用肺力咳合剂,能够在一定程度上提升治疗效果,改善症状,安全性良好。Objective To explore the effect of Feilike Mixture(肺力咳合剂) combined with azithromycin in the treatment of severe mycoplasma pneumonia in children. Methods A total of 102 children with severe mycoplasma pneumonia who were hospitalized in the Pediatrics Department of Hebei Children’s Hospital from January 2018 to November 2019 were selected. According to the method of random numbers, all children were divided into control group and observation group, 51 cases in each group. The children in the control group were treated with azithromycin. The children in the observation group were given Feilike Mixture based on the treatment in the control group. The duration of various symptoms(elevated body temperature, asthma, cough, lung snoring), serum inflammatory factor levels[C-reactive protein(CRP), interleukin-10(IL-10), tumor necrosis factor-α(TNF-α)] before and after treatment in the two groups, adverse reactions during the treatment and effect were compared. Results The duration of "temperature rise", "asthma", "cough" and "lung sounds" in the observation group were shorter than those in the control group(t=2.454,2.422,2.594,2.491, P<0.05). There was no significant difference in CRP, IL-10 or TNF-α before treatment between the two groups(P>0.05). After treatment, CRP and TNF-α were in both groups decreased, and IL-10 was increased. The CRP and TNF-α of the observation group were lower than those of the control group, and the IL-10 was higher than that of the control group. There was no statistically significant difference in the proportion of people who had adverse reactions during the treatment between the two groups(χ^(2)=0.172, P>0.05). The treatment effect of the observation group was better than that of the control group(z=1.864, P<0.05). After treatment, the typical B-ultrasound performance of various lung diseases showed significant improvement. Conclusion In the treatment of patients with severe mycoplasma pneumonia, the combination of azithromycin and Feilike Mixture can improve the treatment

关 键 词：肺力咳合剂 阿奇霉素 儿童 支原体肺炎 中医 

分 类 号：R259.631[医药卫生—中西医结合]