替加环素治疗高龄患者肺炎克雷伯菌感染有效性的影响因素分析  

Analysis of factors influencing the efficacy of tigecycline in the treatment of elderly patients with Klebsiella pneumoniae infection

作　　者：胡波[1] 单青 李晨[1] 陈孟莉[1] HU Bo;SHAN Qing;LI Chen;CHEN Meng-li(Department of Pharmacy,Medical Security Center,Chinese People’s Liberation Army General Hospital,Beijing 100853,China)

机构地区：[1]中国人民解放军总医院医疗保障中心药剂科,北京100853

出　　处：《中国临床药理学杂志》2021年第15期1960-1963,共4页The Chinese Journal of Clinical Pharmacology

基　　金：军队保健课题资助项目(18BJZ23)。

摘　　要：目的探索替加环素治疗高龄患者肺炎克雷伯菌(KP)感染有效性的影响因素。方法收集我院2016-2019年使用替加环素治疗KP感染的全部高龄患者病例,对人口学信息、用药相关信息和疗效评价进行统计,分析影响临床治疗结局的主要因素。结果我院高龄患者KP菌株耐药情况严重,替加环素作为替代治疗多以联合用药为主,在多数按说明书标准给药的情况下,总体临床有效率为66.97%。用药前凝血功能异常是影响临床有效性的独立危险因素。结论针对高龄患者,我院的替加环素用药剂量保守,总体有效率相对较低,其中,合并凝血功能异常患者有更大的可能导致治疗失败。Objective To explore the factors influencing the efficacy of tigecycline in the treatment of elderly patients with Klebsiella pneumoniae(KP)infection.Methods All the elderly patients infected with KP in our hospital from 2016 to 2019 were collected.The demographic information,medication-related information and effectiveness evaluation were analyzed,and the main factors affecting the clinical outcome were analyzed.Results The drug resistance of KP strains in elderly patients in our hospital was serious.Tigecycline was mainly used in combination as alternative therapy.In most cases,the overall clinical effective rate was 66.97%.The coagulation dysfunction before medication was an independent risk factor affecting the effectiveness.Conclusion For elderly patients,the dosage of tigecycline in our hospital is conservative,and the overall effective rate is relatively low.Among them,patients with coagulation dysfunction are more likely to have treatment failure.

关 键 词：替加环素 高龄 肺炎克雷伯菌 抗菌药物 安全有效性 

分 类 号：R978.1[医药卫生—药品]