中药有效成分在抗衰老与抗肿瘤作用机制中的研究进展  

Research progress of effective components of traditional Chinese medicine in anti-aging and anti-tumor mechanism

作　　者：周若宇 孙曼婷 刘静 罗瑛[1,2] ZHOU Ruo-yu;SUN Man-ting;LIU Jing;LUO Ying(Faculty of Environmental Science and Engineering,Kunming University of Science and Technology,Kunming 650500,China;Laboratory of Molecular Genetics of Aging and Tumor,Medical School,Kunming University of Science and Technology,Kunming 650500,China)

机构地区：[1]昆明理工大学环境科学与工程学院,云南昆明650500 [2]昆明理工大学医学院衰老与肿瘤分子遗传学实验室,云南昆明650500

出　　处：《药学学报》2021年第7期1856-1864,共9页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81760662);云南省自然科学基金资助项目(2018FB148).

摘　　要：逐年增加的研究发现衰老与肿瘤之间存在高度关联:细胞衰老可抑制肿瘤发生;衰老细胞改变细胞微环境,促进肿瘤细胞的增殖和转移。衰老和肿瘤在其发生发展过程中享有共同的细胞信号通路,这些信号通路的失调会导致衰老和肿瘤的发生和发展。因此,可平衡调节这些通路的药物可能具有抗衰老和抗肿瘤作用。一些中药有效成分在衰老和肿瘤相关的多种信号通路和分子靶标上均有作用,且不良反应较少。因此,本文对衰老和肿瘤中交叉的细胞信号进行了回顾,并在此基础上总结了目前具有抗衰老和抗肿瘤特性的中药有效成分,以及这些成分在交叉通路中的潜在机制,旨在为中药有效成分治疗衰老和肿瘤提供新的研究策略和视野。Increasing research have found a high correlation between senescence and tumor.Cellular senescence can inhibit tumorigenesis while the cellular microenvironment altered by senescent cells can promote the proliferation and metastasis of tumor cells.Some cellular signaling pathways are commonly involved in aging process and carcinogenesis.The deregulation and imbalance of these pathways results into senescence and tumor development.Thus,agents that balance these pathways may effective for anti-aging and anti-tumor.Traditional Chinese medicine(TCM)has been used for the activation of multiple signaling pathways and molecular targets both associated with aging and tumor,with few side effects.Therefore,the article reviewed the cellular signalings that cross between the aging and tumors,and on this basis,summarized the current effective components of TCM with anti-aging and anticancer properties,as well as the potential mechanisms of these components in the cross signalings,to provide new research strategies and perspectives for effective components of TCM to treat aging and tumors.

关 键 词：中药 有效成分 抗衰老效应 抗肿瘤活性 细胞信号通路 

分 类 号：R285[医药卫生—中药学]