新型冠状病毒肺炎多器官功能损伤机制的研究进展  

Research progress on the mechanism of multiple organ dysfunction in patients with COVID-19

作　　者：陈凯 蒋素文 胡爱荣 Chen Kai;Jiang Suwen;Hu Airong(Graduate School,School of Medicine,Ningbo University,Ningbo 315211,China;Ningbo Institute of Liver Diseases,HwaMei Hospital,University of Chinese Academy of Sciences,Ningbo 315010,China)

机构地区：[1]宁波大学医学院研究生院,315211 [2]中国科学院大学宁波华美医院(宁波市第二医院)宁波市肝病研究所,315010

出　　处：《中华临床感染病杂志》2021年第2期102-106,共5页Chinese Journal of Clinical Infectious Diseases

基　　金：浙江省宁波市共建医学重点学科项目(2016-S04);宁波市领军和拔尖人才工程项目(2015-165)。

摘　　要：新型冠状病毒肺炎(COVID-19)病原体为新型冠状病毒(2019-nCoV),该病毒属于β冠状病毒。与严重急性呼吸综合征冠状病毒一样,2019-nCoV的受体为血管紧张素转化酶2(ACE2),重症患者多为有基础疾病老年人的机制可能与人体内幼稚T细胞数量的减少有关。除肺部症状外,COVID-19还可引发多器官(肝脏、神经系统、心脏和肾脏等)功能损伤甚至衰竭。病毒的直接入侵、"细胞因子风暴"、内皮细胞受损以及ACE2的下调等机制在其重症化中发挥重要作用。The pathogen of COVID-19 is 2019-nCoV,which belongs to the beta coronavirus.Angiotensin-converting enzyme 2(ACE2)is the receptor of 2019-nCoV as the same of SARS-CoV.Most of the severe patients were the elderly with underlying diseases,which may be related to the decrease in the number of naive T cells.In addition to pulmonary symptoms,COVID-19 can also cause multiple organ dysfunction and even multiple organ failure(liver,nervous system,heart,kidney,etc.).Pathogenic mechanisms such as direct virus invasion,cytokine storm,endothelial cells damage,and down-regulation of ACE2 may play important roles in the severity of the disease.

关 键 词：新型冠状病毒肺炎 2019新型冠状病毒 多器官功能损伤 致病机制 

分 类 号：R563.1[医药卫生—呼吸系统]