苏州市区2010-2014年5岁以下儿童流感嗜血杆菌相关社区获得性肺炎的住院率估计  

Estimation of hospitalization rate of Haemophilus influenzae associated community-acquired pneumonia in children under 5 years in Suzhou,2010-2014

作　　者：代子瑞 邵雪君[2] 陶云珍[2] 沈思 冯爽 任少龙 栾琳[3] 张钧[3] 田健美[2] 张涛[1] 赵根明[1] Dai Zirui;Shao Xuejun;Tao Yunzhen;Shen Si;Feng Shuang;Ren Shaolong;Luan Lin;Zhang Jun;Tian Jianmei;Zhang Tao;Zhao Genming(Department of Epidemiology,School of Public Health,Fudan University/Key Laboratory of Public Health Safety,Ministry of Education,Fudan University,Shanghai 200032,China;Department of Infection,Children's Hospital of Soochow University,Suzhou 215003,China;Department of Infectious Disease Prevention and Control,Suzhou Center for Disease Control and Prevention,Suzhou 215004,China)

机构地区：[1]复旦大学公共卫生学院流行病学教研室/公共卫生安全教育部重点实验室,上海200032 [2]苏州大学附属儿童医院感染科,215003 [3]苏州市疾病预防控制中心传染病预防控制科,215004

出　　处：《中华流行病学杂志》2021年第7期1246-1251,共6页Chinese Journal of Epidemiology

基　　金：上海市公共卫生体系建设三年行动计划(2020-2022)重点学科(GWV-10.1-XK16);中美新发和再发传染病合作项目(5U2GGH000018)。

摘　　要：目的估计苏州市区<5岁儿童流感嗜血杆菌相关社区获得性肺炎的住院率。方法回顾性收集2010-2014年因社区获得性肺炎在苏州大学附属儿童医院住院治疗的<5岁儿童的病历资料及细菌学检测结果,描述流感嗜血杆菌的检出情况,并通过苏州市CDC免疫接种平台获取市区儿童人口数,估计流感嗜血杆菌相关社区获得性肺炎的住院率。结果2010-2014年共纳入28043例社区获得性肺炎住院病例,19526例(69.63%)进行了细菌学检测,流感嗜血杆菌总阳性率为11.06%(2160/19526),其中12~23月龄组阳性率最高(14.29%,550/3850),冬、春季高于夏、秋季(χ^(2)=455.11,P<0.01);<5岁儿童流感嗜血杆菌相关社区获得性肺炎的年均住院率为760.36/10万(95%CI:733.70/10万~787.01/10万),冬、春季(898.79/10万、1249.52/10万)高于夏、秋季(514.35/10万、359.04/10万),男性(942.12/10万)高于女性(563.76/10万),差异均有统计学意义(P<0.01),1~5月龄组年均住院率最高(2478.31/10万),随年龄增长住院率逐渐下降(χ^(2)=2129.80,P<0.01)。结论苏州市区<5岁儿童流感嗜血杆菌相关社区获得性肺炎住院率较高,<6月龄组住院率最高。Objective To estimate the hospitalization rate of Haemophilus(H.)influenzae associated community-acquired pneumonia in children under 5 years in Suzhou.Methods From 2010 to 2014,medical records and bacteriology results of children under 5 years hospitalized with community-acquired pneumonia in Children's Hospital of Soochow University were collected,retrospectively.Detection rate of H.influenzae was describe.The hospitalization rate of H.influenzae associated community-acquired pneumonia was estimated using the number of local children in urban area of Suzhou,which was obtained from the immunization platform of Suzhou Center for Disease Prevention and Control.Results A total of 28043 hospitalized pneumonia cases were included from 2010 to 2014,in which 19526(69.63%)had bacteriological examination.The overall detection rate of H.influenzae was 11.06%(2160/19526),and children aged 12-23 months had the highest positive rate(14.29%,550/3850),and the rate was higher during winter-spring than during summer-autumn(χ^(2)=455.11,P<0.01).The average hospitalization rate of H.influenzae associated pneumonia in children under 5 years was 760.36/100000(95%CI:733.70/100000-787.01/100000),which was higher in winter and spring(898.79/100000 and 1249.52/100000)than in summer and autumn(514.35/100000 and 359.04/100000),and the hospitalization rate was higher in boys(942.12/100000)than in girls(563.76/100000),the differences were all significant(P<0.01).The highest hospitalization rate was observed in children aged 1-5 months(2478.31/100000)and the hospitalization rate decreased with age(χ^(2)=2129.80,P<0.01).Conclusion There was a considerable burden of H.influenzae associated community-acquired pneumonia in children under 5 years in Suzhou,especially in children under 6 months.

关 键 词：流感嗜血杆菌 社区获得性肺炎 住院率 儿童 

分 类 号：R725.6[医药卫生—儿科]