银杏提取物中银杏酚酸类物质的毒性和药理活性研究进展  

Research Progress of Toxicity and Pharmacological Activity of Ginkgolic Acids in Ginkgo Extract

作　　者：李颜[1] 郭澄[1] LI Yan;GUO Cheng(Department of Pharmacy,Shanghai Sixth People′s Hospital,Shanghai,China 200233)

机构地区：[1]上海市第六人民医院药剂科,上海200233

出　　处：《中国药业》2021年第16期1-5,共5页China Pharmaceuticals

基　　金：国家自然科学基金[81873042]。

摘　　要：目的进一步研究和开发银杏酚酸类物质。方法查阅相关文献,对银杏提取物中酚酸类物质的毒性及药理活性进行分析及综合评价。结果银杏提取物中酚酸类物质对模型动物具有一定的致敏作用及肝毒性。体外实验表明,其还具有一定的抗肿瘤、抗炎杀菌、神经保护、抗寄生虫、抗氧化等药理活性。结论现有银杏提取物中酚酸类物质的毒性和药理活性研究多为体外实验,全面、合理地开发和利用银杏酚酸类物质还需进一步的体内实验和临床研究。Objective To provide a reference for the further development of ginkgolic acids.Methods The toxicity and pharmacological activity of ginkgolic acid in ginkgo extract were analyzed and comprehensively evaluated by consulting the relevant literature.Results Ginkgolic acids in ginkgo extract had a certain sensitization effect and hepatotoxicity to model animals.In vitro tests showed that it also had anti-tumor,anti-inflammatory and bactericidal,neuroprotective,anti-parasite,anti-oxidant and other pharmacological activities.Conclusion The existing research reports on the toxicity and pharmacological activity of ginkgolic acids in ginkgo extract are mostly in vitro.The comprehensive and rational development and utilization of ginkgolic acids need further in vivo and clinical research.

关 键 词：银杏提取物 银杏酚酸 毒性 药理活性 

分 类 号：R932[医药卫生—生药学] R285.5[医药卫生—药学]