Rational Design of Biomolecules/Polymer Hybrids by Reversible Deactivation Radical Polymerization (RDRP) for Biomedical Applications  

作　　者：Jie Zhou Xiao-Yuan Zhang Zhi-Qiang Su 

机构地区：[1]State Key Laboratory of Chemical Resource Engineering,Beijing Key Laboratory of Advanced Functional Polymer Composites,Beijing University of Chemical Technology,Beijing 100029,China

出　　处：《Chinese Journal of Polymer Science》2021年第9期1093-1109,共17页高分子科学（英文版）

基　　金：ZQS acknowledges the financial supports from the National Natural Science Foundation of China(NSFC,No.51873016);the Fundamental Research Funds for the Central Universities(No.JD2014);the Joint Project of BRC-BC(Biomedical Translational Engineering Research Center of BUCT-CJFH)(No.XK2020-11).

摘　　要：Hybrids,produced by hybridization of proteins,peptides,DNA,and other new biomolecules with polymers,often have unique functional properties.These properties,such as biocompatibility,stability and specificity,lead to various smart biomaterials.This review mainly introduces biomolecule polymer hybrid materials by reversible deactivation radical polymerization(RDRP),emphasizing reverse addition-fragmentation chain transfer(RAFT)polymerization,and nitroxide mediated polymerization(NMP).It includes the methods of RDRP to improve the biocompatibility of biomedical materials and organisms by surface modification.The key to the current synthesis of biomolecule polymer hybrids is to control polymerization.Besides,this review describes several different kinds of biomolecule polymer hybrid materials and their applications in the biomedical field.These progresses provide ideas for the investigation of biodegradable and highly bioactive biomedical soft tissue materials.The research hotspots of nanotechnology in biomedical fields are controlled drug release materials and gene therapy carrier materials.Research showed that RDRP method could improve the therapeutic effect and reduce the dosage and side effects of the drug.Specifically,by means of RDRP,the original materials can be modified to develop intelligent polymer materials as membrane materials with selective permeability and surface modification.

关 键 词：Biomolecule-polymer hybrids RDRP Biomedical applications Drug release Nanotechnology 

分 类 号：TQ316.322[化学工程—高聚物工业] R318[医药卫生—生物医学工程]