Analysis of uterine CD49a^(+) NK cell subsets in menstrual blood reflects endometrial status and association with recurrent spontaneous abortion  

作　　者：Xianhong Tong Min Gao Xianghui Du Fangting Lu Limin Wu Haiming Wei Binqing Fu 

机构地区：[1]The Department of Obstetrics and Gynecology,First Affiliated Hospital of University of Science and Technology of China,University of Science and Technology of China,Hefei,China [2]Anhui Provincial Hospital Affiliated to Anhui Medical University,Hefei,Anhui,China [3]Hefei National Laboratory for Physical Sciences at Microscale,the CAS Key Laboratory of Innate Immunity and Chronic Disease,School of Basic Medical Sciences,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,China [4]Institute of Immunology,University of Science and Technology of China,Hefei,China

出　　处：《Cellular & Molecular Immunology》2021年第7期1838-1840,共3页中国免疫学杂志（英文版）

基　　金：supported by the National Key Research&Developmental Program of China(no.2018YFC1003900 to H.W.);the National Natural Science Foundation of China(81930037 to H.W.;31870914,81922028 to B.F.);Youth Innovation Promotion Association of Chinese Academy of Sciences(Grant 2019442 to B.F.).

摘　　要：Maternal uterine immune cells,especially natural killer(NK)cells,are important for successful pregnancy,and an abnormal number or function of uterine NK cells is closely correlated with an impaired endometrial environment and miscarriage.However,there are currently no noninvasive testing methods using reliable indicators that accurately predict uterine changes leading to miscarriage.Here,we confirmed that before implantation,menstrual blood(MB)from healthy donors had 70%CD49a^(+)tissue-resident NK(trNK)cells,the majority of which were CD49a^(+)Eomes+NK cells.Importantly,MB from patients with recurrent spontaneous abortion(RSA)had many fewer CD49a^(+)trNK cells than MB from controls.Analysis of uNK cell populations in MB may better predict an abnormal endometrial environment associated with miscarriage than peripheral blood(PB)analysis.Therefore,we suggest using MB-and CD49a-related markers as a promising noninvasive way to evaluate endometrial status.

关 键 词：ENDOMETRIAL UTERINE IMPAIRED 

分 类 号：R714.21[医药卫生—妇产科学]