ICP-MS法分析伊贝母中的21种无机元素  

Determination of 21 inorganic elements in Fritillariae pallidiflorae Bulbus by ICP -MS

作　　者：李小红[1,2] 罗意玲[1] 耿昭 郭晓强 梁羽佳[1] 郭力 周闯[1] LI Xiaohong;LUO Yiling;GENG Zhao;GUO Xiaoqiang;LIANG Yujia;GUO Li;ZHOU Chuang(School of Food and Biological Engineering,Chengdu University,Chengdu,Sichuan,610106 P.R.China;Pharmacy College,Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan,611137 P.R.China;Sichuan Institute for Food and Drug Control,Chengdu,Sichuan,611731 P.R.China)

机构地区：[1]成都大学食品与生物工程学院,四川成都610106 [2]成都中医药大学药学院,四川成都611137 [3]四川食品药品检验检测院,四川成都611731

出　　处：《华西药学杂志》2021年第4期447-452,共6页West China Journal of Pharmaceutical Sciences

基　　金：四川省科技厅重点研发项目(2019YFS0525);成都市技术创新研发项目(2018-YF05-01510-GX);成都大学校基金项目(2017XJZ03)。

摘　　要：目的采用电感耦合等离子体质谱法(ICP-MS)测定伊贝母药材中的21种无机元素,并对各元素进行分析和评价。方法样品经微波消解后,采用ICP-MS法测定伊贝母中21种无机元素的含量,运用SPSS 26.0对数据进行主成分分析(PCA)和相关性分析。结果伊贝母间无机元素的组成大体相同,其中以K、Na、Ca、Al、Fe的含量较为丰富,但所有样品中均未检出Sn、Sb、Tb、Be。PCA选出4个主因子,Fe、Pb、Al、Cd、B、Mo、Se、Na为伊贝母的特征元素。结论所用方法可准确、高效地评价伊贝母中的无机元素,为其品种选育、质量控制和综合利用提供了科学依据。OBJECTIVE To detect 21 inorganic elements in Fritillariae pallidiflorae Bulbus(FPB)by inductively coupled plasma mass spectrometry(ICP-MS),and to analyze and evaluate the elements.METHODS ICP-MS was used to determine the content of 21 inorganic elements in the samples after microwave digestion.Principal component analysis(PCA)and correlation analysis were performed using SPSS 26.0.RESULTS There were almost no differences in the types of inorganic elements in the samples of FPB.Among the 21 elements,K,Na,Ca,Al and Fe were abundant,while Sn,Sb,Tb and Be were not detected in any samples.Four principal factors were selected by PCA,and Fe,Pb,Al,Cd,B,Mo,Se and Na were the characteristic elements.CONCLUSION The method is accurate and efficient for the analysis and evaluation of inorganic elements in FPB,which provides a scientific reference for the breeding,quality control and comprehensive utilization of FPB.

关 键 词：伊贝母 无机元素 微波消解 电感耦合等离子体质谱 主成分分析 相关性分析 重金属 质量控制 

分 类 号：R917[医药卫生—药物分析学]