岩黄连总生物碱对中枢抑制作用的初步研究  

Study on the Inhibition of Total Alkaloids of Corydalis sax icola Bu nting on Central Nervous System

作　　者：庞彩萍 蒙田秀[1] 谢理名 曾浩 李小敏 滕丽娟[1] PANG Cai-ping;MENG Tian-xiu;XIE Li-ming;ZENG Hao;LI Xiao-min;TENG Li-juan(Faculty of Chinese Medical Science Guangxi University Chinese Medical,Nanning 530222,China)

机构地区：[1]广西中医药大学赛恩斯新医药学院,广西南宁530222

出　　处：《海峡药学》2021年第7期21-23,共3页Strait Pharmaceutical Journal

基　　金：2019年广西壮族自治区大学生创新创业项目(201913643054)。

摘　　要：目的以岩黄连总生物碱(Total alkaloids of Corydalis saxicola Bunting,TACS)为研究对象,考察其对中枢的抑制作用。方法灌胃给药后,观察TACS对小鼠自发活动的影响和对戊巴比妥钠诱导对睡眠时相的影响以及对抗尼可刹米导致小鼠惊厥实验。结果TACS可以减少小鼠自主活动次数,延长小鼠睡眠时间,对抗尼可刹米所致的惊厥。结论TACS对中枢有一定的抑制作用。OBJECTIVE Take total alkaloids of Corydalis saxicola Bunting(TACS)as the research object,and study its inhibitory effect on the central.METHODS After gavage administration,the effects of TACS on spontaneous activity,pentobarbital sodium induction on sleep phase,and the convulsion induced by antagonism to nikethamite in mice were observed.RESULTS TACS could reduce the number of spontaneous activity,prolong the sleep time of mice,and resist the convulsion caused by Nicephthalamic acid.CONCLUSION TACS has a certain inhibitory effect on the CNS.

关 键 词：岩黄连 总生物碱 中枢抑制 

分 类 号：R965[医药卫生—药理学]