环境镉暴露影响辅助生殖结局及生殖毒性的研究进展  

Research progress of environmental cadmium exposure impacting on ART outcomes and reproductive toxicity

作　　者：李丹阳 梁春梅[1,2,3] 纪冬梅 许孝凤[1,2,3] LI Dan-yang;LIANG Chun-mei;JI Dong-mei;XU Xiao-feng(Department of Obstetrics and Gynecology,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230032,China)

机构地区：[1]安徽医科大学第一附属医院妇产科,合肥230032 [2]国家卫生健康委配子及生殖道异常研究重点实验室 [3]出生人口健康教育部重点实验室 [4]生殖健康与遗传安徽省重点实验室 [5]安徽省生命资源保存与人工器官工程技术研究中心

出　　处：《现代预防医学》2021年第15期2716-2719,共4页Modern Preventive Medicine

基　　金：国家重点研发计划项目(2017YFC1001300)。

摘　　要：人类辅助生殖技术(ART)是运用医学技术和方法对配子、合子、胚胎进行人工操作,以达到受孕目的的技术。而镉是一种非必需的痕量金属,在生物体内具有致畸和致突变作用。镉会在生殖器官中蓄积发挥生殖毒性,孕期镉暴露会影响通过ART助孕的患者。本文系统地回顾了已发表的有关ART结局与镉影响胎盘及胚胎发育的关联研究,并总结了相关的机制,对于制定预防和控制不孕症女性镉暴露导致辅助生殖技术失败的策略具有一定的理论支持和参考价值。Human assisted reproductive technology(ART)is a technique to achieve the purpose of conception by the medical methods of operating gametes,zygotes and embryos.Cadmium is a non-essential trace metal with strong teratogenic and mutagenic effects on organisms.The accumulation of cadmium in reproductive tissue can bring reproductive toxicity.Exposure to cadmium during pregnancy can affect patients undergoing ART assisted pregnancy.This paper systematically reviewed the relationship between ART outcomes and the impact of cadmium on placenta and embryo development,and summarized the relevant mechanisms,which would provide certain theoretical support and reference value for the development of strategies to prevent and control the failure of ART caused by cadmium exposure in sterile women.

关 键 词：镉 环境暴露 女性生殖 辅助生殖技术 

分 类 号：R173[医药卫生—妇幼卫生保健]