孕前BMI联合打鼾与GDM风险及糖代谢的关联研究  

Association between pre-pregnancy BMI combined with snoring and the risk of GDM and glucose metabolism

作　　者：李培 解钧[1,2,3] 李蕾 周美婷 黄大雁[4] 纪瑞云 张一墨 陶瑞雪 朱鹏 LI Pei;XIE Jun;LI Lei;ZHOU Mei-ting;HUANG Da-yan;JI Rui-yun;ZHANG Yi-mo;TAO Rui-xue;ZHU Peng(Department of Maternal,Child and Adolescent Health,School of Public Health,Anhui Medical University,Hefei,Anhui 230032,China)

机构地区：[1]安徽医科大学公共卫生学院儿少卫生与妇幼保健学系,安徽合肥230032 [2]出生人口健康教育部重点实验室(安徽医科大学) [3]人口健康与优生安徽省重点实验室(安徽医科大学) [4]安徽医科大学附属妇幼保健院 [5]合肥市第一人民医院妇产科

出　　处：《现代预防医学》2021年第15期2745-2749,2790,共6页Modern Preventive Medicine

基　　金：国家自然科学基金(81872631,81472991);安徽省高校优秀青年人才基金重点项目(gxyqZD2018025);安徽省学术和技术带头人后备人选科研资助项目(2017H141);合肥市卫计委应用医学研究项目(hwk2018zd002)。

摘　　要：目的探讨孕前体质指数(body mass index,BMI)联合打鼾与妊娠期糖尿病(gestational diabetes mellitus,GDM)发生风险及糖代谢指标的关系。方法招募2015年3月至2019年6月在合肥市三家医院产检的5987例孕中期孕妇,问卷调查收集基本特征信息,记录GDM发生情况。结果孕中期打鼾和GDM发生率分别为24.4%和20.6%。以孕前低体重且非打鼾组为对照,孕前超重肥胖合并非打鼾、孕前正常体重合并打鼾及孕前超重肥胖合并打鼾组的GDM风险逐渐升高,分别为1.57(95%CI:1.19~2.06)、2.40(95%CI:1.81~3.19)和2.85(95%CI:2.09~3.88)。此外,打鼾及非打鼾孕妇GDM发生风险显著增加时的孕前BMI节点分别为23.73 kg/m^(2)和24.41 kg/m^(2)。结论孕前BMI联合打鼾可进一步增加GDM发生风险。与非打鼾孕妇相比,打鼾孕妇合并更低的孕前BMI时,GDM风险即显著增加。Objective To explore the relationship between pre-pregnancy BMI combined with snoring and the risk of GDM and glucose metabolism.Methods From March 2015 to June 2019,a total of 5987 pregnant women in the second trimester were recruited from 3 hospitals in Hefei.Questionnaires were used to collected the basic characteristic information,and the occurrence of GDM were recorded.Results The incidence of snoring and GDM were 24.4%and 20.6% in the second trimester,respectively.Taking pre-pregnancy low-weight with non-snoring pregnant women as controls,the GDM risk of pre-pregnancy overweight and obesity combined with non-snoring,pre-pregnancy normal weight combined with snoring,and pre-pregnancy overweight and obesity combined with snoring pregnant women gradually increased,respectively,1.57(95%CI:1.19-2.06),2.40(95%CI:1.81-3.19)and 2.85(95%CI:2.09-3.88).In addition,the pre-pregnancy BMI node was 23.73 kg/m^(2) when the risk of GDM was significantly increased in snoring women,while the pre-pregnancy BMI node was 24.41 kg/m^(2) in non-snoring women.Conclusion Pre-pregnancy BMI combined with snoring can further increase the risk of GDM.Compared with non-snoring pregnant women,when snoring pregnant women have a lower pre-pregnancy BMI,the risk of GDM is significantly increased.

关 键 词：孕前体质指数 打鼾 血糖 妊娠期糖尿病 

分 类 号：R173[医药卫生—妇幼卫生保健] R714.256[医药卫生—公共卫生与预防医学]