药代动力学-药效学模型在制定及优化抗菌药物给药方案中的应用  

Application of PK-PD Model in Formulation and Optimization of Antimicrobial Drug Dosing Regimen

作　　者：王芳 刘亚娜[1,2] 吴香云 潘源虎 黄玲利[1,2] 郝海红[1,2] 谢书宇[1,2] 王玉莲 WANG Fang;LIU Ya-na;WU Xiang-yun;PAN Yuan-hu;HUANG Ling-li;HAO Hai-hong;XIE Shu-yu;WANG Yu-lian(College of Veterinary Medicine,Huazhong Agricultural University,Wuhan,Hubei,430070,China;National Reference Laboratory of Veterinary Drug Residues(HZAU),MOA Key Laboratory for the Detection of Veterinary Drug Residues,Huazhong Agricultural University,Wuhan,Hubei,430070,China)

机构地区：[1]华中农业大学动物医学院,湖北武汉430070 [2]国家兽药残留基准实验室(华中农业大学)/农业农村部兽药残留检测重点实验室,湖北武汉430070

出　　处：《动物医学进展》2021年第7期110-114,共5页Progress In Veterinary Medicine

基　　金：“十三五”国家重点研发计划项目(2017YFD0501401)。

摘　　要：抗菌药物的不合理使用,造成了细菌耐药性暴发和药物残留增加,这不仅降低了畜牧业生产,而且危害着人类的身体健康。制定合理健全的药物剂量给药方案能够缓解抗菌药物使用所面临的巨大压力,而药动学和药效学(PK-PD)模型能够对作用时间、药物浓度和治疗效果之间的内在关系进行拟合和定量分析,更加客观和科学地评价药物在体内的动态变化过程和作用效果。它在抗菌药物的合理使用,减少药物的耐药性产生和新药物的研发方面发挥重要作用。基于前人的研究,对PK-PD模型在兽用抗菌药物给药方案制定及优化方面的应用进行综述,为抗菌药物的使用提供参考依据。The unreasonable use of antimicrobials generally leads to the outbreak of bacterial drug resistance and the increase of drug residues,which not only reduces the production of animal husbandry,but also endangers the health of human beings.A reasonable and sound drug dose administration scheme must be established,which can alleviate the huge pressure faced by the use of antibacterial drugs.And the internal relationship among time,drug concentration and therapeutic effect is fitted and quantitatively analyzed by pharmacokinetic-pharmacodynamic(PK-PD)model,and the dynamic process and effect of drugs in vivo are evaluated more objectively and scientifically,which plays an important role in the rational use of antimicrobials,reducing drug resistance and the research and development of new drugs.Based on previous studies,the application of the PK-PD model in the formulation and optimization of veterinary antibacterial drug dosing schedules was discussed,which can help provide a reference for the research of veterinary antibacterial drugs.

关 键 词：抗菌药物 药动学-药效学模型 合理用药 耐药性 

分 类 号：S859.79[农业科学—临床兽医学] S859.1[农业科学—兽医学]