410例维生素B6注射液不良反应分析  

Analysis on 410 Cases of Adverse Reactions Resulting from Vitamin B6 Injection

作　　者：殷园园 火红艳 于萍 YIN Yuanyuan;HUO Hongyan;YU Ping(Center for Food and Drug Inspection of Yunnan Province,Kunming,Yunnan,China 650000;The Second People's Hospital of Yuxi,Yuxi,Yunnan,China 653100;Center for Drug Reevaluation of Yunnan Province,Kunming,Yunnan,China 650000)

机构地区：[1]云南省食品药品审核查验中心,云南昆明650000 [2]玉溪市第二人民医院,云南玉溪653100 [3]云南省药品评价中心,云南昆明650000

出　　处：《昆明学院学报》2021年第3期119-124,共6页Journal of Kunming University

摘　　要：为探讨维生素B6注射液不良反应的规律、特点及其发生不良反应的原因.对患者的性别、年龄、给药剂量、给药途径、溶媒、联合用药、药品不良反应临床表现以及不良反应发生时间与转归进行统计分析.结果表明,维生素B6注射液不良反应女性高于男性,以皮肤及其附件损害、全身性损害和胃肠系统损害为多见.临床表现复杂多样,药品不良反应发生与给药剂量、溶媒、联合用药等密切相关.说明维生素B6注射液引发的不良反应原因较复杂,在临床使用过程中应加强科学用药指导,建议药品生产企业完善药品说明书,保证药物疗效的同时保证患者用药安全.To investigate the regularity and characteristics of adverse reactions as well the causes leading to the adverse reactions of vitamin B6 injection,the gender and age of patients,the dosage,delivery route,solvent,the combination of the injection,the clinical manifestations of adverse drug reaction(ADR)and the occurrence time and outcome of ADR were statistically analyzed.The results showed that the probability of adverse reactions of vitamin B6 injection in women were higher than that in men.The most common adverse reactions were in skin and its accessories damage,systemic damage and gastrointestinal system damage.The clinical manifestations were complex and diverse,and the occurrence of ADR was closely related to the dosage,the solvent and the combination of the injection.Investigating showed that the reasons of adverse reactions caused by vitamin B6 injection are complex.In the process of clinical use,scientific medication guidance should be strengthened,and relevant manufacturers should improve instructions of the drug to ensure its efficacy and the safety of patients.

关 键 词：维生素B6注射液 临床应用 不良反应 分析 

分 类 号：R977.22[医药卫生—药品]