铱催化的(杂)芳烃远端区域选择性C—H硼化反应的最新进展  

Recent Progress in Iridium-Catalyzed Remote Regioselective C—H Borylation of(Hetero)Arenes

作　　者：邹晓亮 徐森苗 Zou Xiaoliang;Xu Senmiao(State Key Laboratory for Oxo Synthesis and Selective Oxidation,Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences,Lanzhou 730000;University of Chinese Academy of Sciences,Beijing 100049)

机构地区：[1]中国科学院兰州化学物理研究所羰基合成与选择氧化国家重点实验室,兰州730000 [2]中国科学院大学,北京100049

出　　处：《有机化学》2021年第7期2610-2620,共11页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.91956116)资助项目.

摘　　要：(杂)芳基硼酸及其衍生物在合成化学、材料科学和药物化学领域具有广泛的用途,因此,其合成方法研究一直备受关注.铱催化的C—H硼化反应是合成这类化合物最为有效的途径之一,然而,由于反应机理的限制,区域选择性可控的C—H硼化是铱催化体系的一大挑战,同时也是该领域的一个重要发展方向.系统介绍了最近几年铱催化的芳烃远端硼氢化反应的最新进展.(Hetero)Aryl boronic acids and their derivatives have been widely used in synthetic chemistry,material sciences,and drug discovery.Accordingly,the development of novel synthetic methods towards these structures has received a great deal of attention.In particular,Ir-catalyzed C—H borylation represents one of the most efficient methods.Due to the restriction of the reaction mechanism,regioselective controllable C—H borylation of Ir catalysis is a formidable challenge,and it is also an important development direction in this area.In this review,the recent progress in Ir-catalyzed remote selective C—H borylation of arenes is systematically discussed.

关 键 词：碳氢键活化 (杂)芳基硼酸酯 合成方法 硼化 

分 类 号：O621.251[理学—有机化学]