倍半萜生物碱Dendrobine的全合成研究进展  

Advances on the Total Synthesis of Sesquiterpenoid Alkaloid Dendrobine

作　　者：肖检 彭羽 李卫东[1,2] Xiao Jian;Peng Yu;Li Wei-Dong Z.(Engineering Research Center Biomimetic Synthesis of Natural Drugs of Sichuan Province,School of Life Science and Engineering,Southwest Jiaotong University,Chengdu 610031;Key Lab of Natural Product Chemistry and Application in Xinjiang,Yili Normal University,Yining,Xinjiang 835000)

机构地区：[1]西南交通大学生命科学与工程学院四川省天然药物仿生合成工程研究中心,成都610031 [2]伊犁师范大学新疆天然产物化学与应用重点实验室,新疆伊宁835000

出　　处：《有机化学》2021年第7期2636-2649,共14页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21772078);中央高校基本科研业务费专项资金(Nos.2682019CX70,2682019CX71,2682020CX55);新疆维吾尔自治区高校科研计划项目(重点项目)(No.XJEDU2018I018)资助项目.

摘　　要：石斛碱(Dendrobine)是一类从传统中药金钗石斛中分离得到的具有Picrotoxane倍半萜碳骨架的生物碱类天然产物.由于该化合物具有多环稠合和七个连续立体中心的结构特点,以及镇痛和退热等药理活性,引起了众多有机合成化学家和药物化学家的关注.五十年来,天然产物Dendrobine的药理活性研究和化学合成不断涌现,主要总结了天然产物Dendrobine的生源途径和合成研究进展.Dendrobine is an important sesquiterpenoid alkaloid bearing the picrotoxane carbon skeleton isolated from the traditional Chinese medicine“Chin-Shih-Hu”.Because of structural characteristics of fused polycyclic and seven contiguous stereocenters,and exhibiting analgesic,antipyretic activities,dendrobine has attracted a great deal of attentions from both synthetic organic chemists and medicinal chemists.Over the past 50 years,there has been a number of research reports on the pharmacological activities and chemical synthesis of dendrobine.This review summarizes the biosynthetic hypothesis and synthetic advances on dendrobine.

关 键 词：天然产物 倍半萜生物碱 石斛碱 全合成 木防己毒烷 

分 类 号：TQ283[化学工程—有机化工]