铁催化1,3-共轭烯烃的Heck型脱羧烷基化反应  

Iron-Catalyzed Decarboxylative Heck-Type Alkylation of Conjugate 1,3-Dienes

作　　者：王凯凯 陈绍维[2] 李亚军[2] 李达谅 鲍红丽[2] Wang Kaikai;Chen Shaowei;Li Yajun;Li Daliang;Bao Hongli(Biomedical Research Center of South China&College of Chemistry and Materials Science,Fujian Normal University,Fuzhou 350007;Key Laboratory of Coal to Ethylene Glycol and Its Related Technology,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fuzhou 350002)

机构地区：[1]福建师范大学南方生物医学研究中心&化学与材料学院,福州350007 [2]中国科学院福建物质结构研究所煤制乙二醇重点实验室,福州350002

出　　处：《有机化学》2021年第7期2707-2714,共8页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21871258,21922112,22001251);福建师范大学校创新团队(No.IRTL1703)资助项目.

摘　　要：报道了铁催化的烷基过氧酰或者叔丁基过氧酯对1,3-共轭烯烃的Heck型脱羧烷基化反应.这个方法提供了一个有效的对1,3-共轭烯烃进行Heck型烷基化的途径,不但收率高,而且有些情况下具有很高的区位选择性.此方法也可以用来对生物活性分子进行后期Heck型烷基化修饰.An iron-catalyzed decarboxylative Heck-type alkylation of conjugate 1,3-dienes with alkyl diacyl peroxides and t-butyl peresters is reported.This method offers an efficient approach to alkylation of 1,3-dienes with good yields,and in some cases with high selectivities.Late-stage alkylation of bioactive compounds was also found to be effective.

关 键 词：铁催化 1 3-共轭烯烃 Heck型烷基化 脱羧反应 过氧酯 过氧酰 

分 类 号：O621.251[理学—有机化学]