铜咔咯催化烯丙基sp3-C—H键与羧酸的酯化反应  

Copper Corrole as an Efficient Catalyst for Esterification of Allylic sp3-C—H Bonds with Carboxylic Acids

作　　者：田婉群 李梦媛 杨霜 章浩 刘海洋 肖新颜 Tian Wanqun;Li Mengyuan;Yang Shuang;Zhang Hao;Liu Haiyang;Xiao Xinyan(Key Laboratory of Functional Molecular Engineering of Guangdong Province,School of Chemistry and Chemical Engineering,South China University of Technology,Guangzhou 510641)

机构地区：[1]华南理工大学化学与化工学院广东省功能分子工程重点实验室,广州510641

出　　处：《有机化学》2021年第7期2875-2884,共10页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21671068,21878115)资助项目.

摘　　要：研究了5,10,15-三(五氟苯基)咔咯铜配合物(CuTPFC)催化的烯丙基sp3杂化C—H键与羧酸的氧化交叉脱氢偶联反应(CDC).该反应可以平稳地生成烯丙基酯,且具有广泛的底物范围和良好的官能团耐受性.克级实验中,在催化剂的用量仅为0.01 mol%的情况下,转换量(TON)可以达到5100,表明目前的催化体系在烯丙基酯合成方面具有潜在的应用前景.Copper 5,10,15-tris(pentafluorophenyl)corrole(CuTPFC)catalyzed oxidative cross dehydrogenative coupling(CDC)of allylic sp3-C—H bonds and acids had been investigated in a homogeneous system,which provided allylic esters smoothly.This reaction proceeded with broad substrate scope and good functional group tolerance.In a gram scale test,the turnover number(TON)reached 5100 at only 0.01 mol%catalyst loading,indicating the current catalytic system has potential uses in the allylic esters.

关 键 词：铜 咔咯 交叉脱氢偶联 烯丙基化合物 催化 

分 类 号：O621.251[理学—有机化学]