毛华菊中倍半萜内酯类化学成分研究  

Sesquiterpene Lactones from Dendranthema vestitum(Hemsl.)Ling

作　　者：刘文琪 佘嘉祎 杨英 朱世明[1,2] 熊校勤 谭芬 张洪权[1,2] 杨新洲 曾国平[1,2] Liu Wenqi;She Jiayi;Yang Ying;Zhu Shiming;Xiong Xiaoqin;Tan Fen;Zhang Hongquan;Yang Xinzhou;Zeng Guoping(Department of Chemistry and Life Science,Hubei University of Education,Wuhan 430205;Hubei Key Laboratory of Purification and Application of Plant Anti-cancer Active Ingredients,Wuhan 430205;College of Pharmacy,South-Central University for Nationalities,Wuhan 430074)

机构地区：[1]湖北第二师范学院化学与生命科学学院,武汉430205 [2]植物抗癌活性物质提纯与应用湖北省重点实验室,武汉430205 [3]中南民族大学药学院,武汉430074

出　　处：《有机化学》2021年第7期2898-2904,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21602052,81903115);湖北省教育厅科学技术研究(No.B2019178);湖北省大学生创新创业训练计划(No.S202014099006)资助项目.

摘　　要：采用溶剂提取法,Diaion HP-20、Sephadex LH-20葡聚糖凝胶、硅胶及制备高效液相等色谱方法,对毛华菊的化学成分进行分离纯化,并利用现代波谱技术对已分离得到的化合物进行结构鉴定.从毛华菊的氯仿部位分离得到4个新化合物,其结构类型属于愈创木内酯衍生物,分别命名为(1S,5R,6S,7S,10S)-愈创木-3,11(13)-二烯-2-酮-12,6-内酯(1)、(1S,5R,6R,7R,8S,10S)-8-异丁酰氧基-愈创木-3,11(13)-二烯-2-酮-12,6-内酯(2)、(1S,5R,6R,7R,8S,10S)-8-(2'-甲基)丁酰氧基-愈创木-3,11(13)-二烯-2-酮-12,6-内酯(3)和(1R,5R,6R,7R,8S,10S,11S)-8-乙酰氧基-愈创木-3-烯-2-酮-12,6-内酯(4),以及2个已知化合物matricarin(5)和11,13-dehydromatricarin(6).The chemical constituents from Dendranthema vestitum(Hemsl.)Ling were isolated and purified by solvent extraction,Diaion HP-20,Sephadex LH-20,silica gel and preparative high performance liquid chromatography.Their structures were elucidated based on their spectroscopic data.Four new compounds which belong to guaianolide,named as(1S,5R,6S,7S,10S)-2-oxo-guaia-3,11(13)-dien-12,6-olide(1),(1S,5R,6R,7R,8S,10S)-2-oxo-8-isobutyryloxy-guaia-3,11(13)-dien-12,6-olide(2),(1S,5R,6R,7R,8S,10S)-2-oxo-8-(2'-methyl)butyryloxy-guaia-3,11(13)-dien-12,6-olide(3)and(1R,5R,6R,7R,8S,10S,11S)-2-oxo-8-acetoxy-guaia-3-en-12,6-olide(4)together with two known compounds matricarin(5)and 11,13-dehydromatricarin(6)were isolated from chloroform extract of Dendranthema vestitum(Hemsl.)Ling.

关 键 词：毛华菊 倍半萜内酯 愈创木内酯 

分 类 号：R284.1[医药卫生—中药学]