诺丽酵素中两个新的酚类衍生物及其 α-葡萄糖苷酶抑制活性  

Two New Phenolic Derivatives withα-Glucosidase Inhibitory Activities from Noni Juice

作　　者：张斌 周学明[1,2] 余章昕[1,2,3] 李小宝 易继凌[1,2] 黄柯蕾 唐春美 刘晴 陈光英 Zhang Bin;Zhou Xueming;Yu Zhang-Xin;Li Xiaobao;Yi Jiling;Huang Kelei;Tang Chunmei;Liu Qing;Chen Guangying(Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education,College of Chemistry and Chemical Engineering,Hainan Normal University,Haikou 571158;Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province,College of Chemistry and Chemical Engineering,Hainan Normal University,Haikou 571158;Key Laboratory of Tropical Translational Medicine of Ministry of Education,Hainan Medical University,Haikou 571199)

机构地区：[1]海南师范大学化学与化工学院热带药用资源化学教育部重点实验室,海口571158 [2]海南师范大学化学与化工学院热带药用植物化学海南省重点实验室,海口571158 [3]海南医学院热带转化医学教育部重点实验室,海口571199

出　　处：《有机化学》2021年第7期2910-2913,共4页Chinese Journal of Organic Chemistry

基　　金：海南省重点研发项目(No.ZDYF2019165);教育部创新研究团队项目(No.IRT-16R19);国家自然科学基金(Nos.21662012,4186605);海南医学院热带转化医学教育部重点实验室的开放基金(No.2020TTM001);海南省研究生创新研究(No.Hyb2020-54)资助项目.

摘　　要：从诺丽酵素中分离纯化得到两个新的酚类衍生物Noniacid A(1),Noniacid B(2)和一个新天然产物Melilotic acid(3),它们的结构通过多种现代波谱技术进行确定.α-葡萄糖苷酶抑制活性测试结果显示,化合物1和2对α-葡萄糖苷酶具有较强的抑制活性,IC50值分别为242.0和229.3µmol•L^(-1).Two new lactic acid derivatives of noniacids A and B(1 and 2)and a new natural product melilotic acid(3)were obtained from the ethyl acetate extract of the Noni Juice.The structures were elucidated using comprehensive spectroscopic methods,and the absolute configurations were defined by comparing optical rotation with the standard.Compounds 1 and 2 showed significant inhibitory activity againstα-glucosidase enzyme with IC50 values of 242.0 and 229.3µmol•L^(-1),respectively.

关 键 词：诺丽酵素 酚类衍生物 α-葡糖苷酶抑制活性 

分 类 号：O629[理学—有机化学]