Decidualization-derived cAMP regulates phenotypic and functional conversion of decidual NK cells from CD56dimCD16− NK cells  

作　　者：Xueling Jin Liyuan Cui Weijie Zhao Xinyi Li Lu Liu Yanhong Li Qiang Fu Dajin Li Min Yu Meirong Du 

机构地区：[1]NHC Key Lab of Reproduction Regulation(Shanghai Institute of Planned Parenthood Research),Hospital of Obstetrics and Gynecology,Fudan University Shanghai Medical College,Shanghai,China [2]Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases,Shanghai,China [3]Department of Immunology,Binzhou Medical College,Yantai,China [4]Department of Obstetrics and Gynecology,Guangzhou First People’s Hospital,School of Medicine,South China University of Technology,Guangzhou,China [5]State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy,Macao University of Science and Technology,Macao,SAR,China

出　　处：《Cellular & Molecular Immunology》2021年第6期1596-1598,共3页中国免疫学杂志（英文版）

基　　金：supported by the National Basic Research Program of China(2017YFC1001403);the National Nature Science Foundation of China(31970859,81630036,and 91542116);the Innovation-oriented Science and Technology Grant from the NHC Key Laboratory of Reproduction Regulation(CX2017-2);The Strategic Collaborative Research Program of the Ferring Institute of Reproductive Medicine Supported by Ferring Pharmaceuticals and the Chinese Academy of Sciences(FIRMX200504);the funding for the Innovative Research Team of High-level Local Universities in Shanghai and a key laboratory program of the Education Commission of Shanghai Municipality(ZDSYS14005).

摘　　要：In early pregnancy,the decidua is populated by a large number of natural killer cells(NKs),most of which are CD56bright with a strong capacity to secrete cytokines,differing from peripheral and cord blood NK cells(pNKs and cNKs).1,2,3 It is generally believed that uterine NKs are recruited from the peripheral blood and are further educated to develop a decidual NK cell(dNK)-like phenotype in the microenvironment at the maternal-fetal interface.4 However,the defined mechanisms involved in this education remain unclear.

关 键 词：CD56 PREGNANCY FETAL 

分 类 号：R392[医药卫生—免疫学]