靶向药物相关胃肠不良反应的中医防治  

Prevention and Treatment of Traditional Chinese Medicine on Gastrointestinal Adverse Reactions Related to Targeted Drugs

作　　者：姜雨佳 孟恺涵 翟笑枫 JIANG Yujia;MENG Kaihan;ZHAI Xiaofeng(School of Traditional Chinese Medicine,Naval Medical University of PLA,Shanghai 200433,China;Department of Traditional Chinese Medicine Oncology,Changhai Hospital,Naval Medical University of PLA,Shanghai 200433,China)

机构地区：[1]中国人民解放军海军军医大学中医系,上海200433 [2]中国人民解放军海军军医大学第一附属医院中医肿瘤科,上海200433

出　　处：《医药导报》2021年第9期1206-1209,共4页Herald of Medicine

基　　金：上海市卫健委中医药重大临床研究项目[ZY(2018-2020)-CCCX-4003];上海市卫计委中医优势病种培育项目(zybz-2017028)。

摘　　要：靶向药物在肿瘤治疗中的应用越来越广泛,其相关的胃肠不良反应也成为临床有待解决的问题。靶向药物常见的消化道不良反应包括腹泻、恶心呕吐、食欲不振等,其发病机制与胃肠道黏膜损伤有关。中医药在防治靶向药物相关不良反应方面具有明显优势,通过辨证论治,结合内服外用不同特色技术,取得明显疗效,可以提高患者生存质量,提高肿瘤治疗的综合疗效。该文就靶向药物引起的胃肠不良反应的机制、表现及中医防治进行探讨。With the more and more extensive application of targeted drugs in tumor treatment,its related gastrointestinal adverse reactions have become a clinical problem.The common adverse reactions of targeted drugs include diarrhea,nausea and vomiting,loss of appetite,etc.;and their pathogenesis is related to the injury of gastrointestinal mucosa.Traditional Chinese medicine(TCM)has obvious advantages in the prevention and treatment of targeted drug-related adverse reactions.Through its advantages in syndrome differentiation and combining different characteristic technologies for internal and external use,significant curative effects can be achieved by TCM,which can improve the quality of life of patients and improve the comprehensive curative effect of tumor treatment.The mechanism,manifestations,and TCM prevention and treatment of gastrointestinal adverse reactions caused by targeted drugs were discussed in this paper.

关 键 词：靶向药物 胃肠不良反应 中医治疗 

分 类 号：R256.3[医药卫生—中医内科学] R979.1[医药卫生—中医学]