基于siRNA经皮给药系统用于皮肤疾病治疗的研究进展  

Research Progress of siRNA Treatment for Skin Diseases Based on Transdermal Drug Delivery System

作　　者：任会红 张瑜娟[2,3,4] 闵卫平 REN Huihong;ZHANG Yujuan;MIN Weiping(School of Pharmacy,Nanchang University,Nanchang 330006,China;Department of Immunology,School of Basic Medicine,Nanchang University,Nanchang 330006,China;Institute of Immunology and Biotherapy,Nanchang University,Nanchang 330006,China;Key Laboratory of Immunology and Biotherapy of Jiangxi Province, Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学药学院,南昌330006 [2]南昌大学基础医学院免疫学教研室,南昌330006 [3]南昌大学免疫与生物治疗研究所,南昌330006 [4]南昌大学江西省免疫与生物治疗重点实验室,南昌330006

出　　处：《医药导报》2021年第9期1232-1236,共5页Herald of Medicine

基　　金：江西省青年科学基金资助项目(20192ACB21027)。

摘　　要：小干扰RNA(siRNA)以参与RNA干扰(RNAi)的方式调节基因表达,使靶信使RNA(mRNA)进行特异性降解,近来已被用于多种皮肤疾病的治疗。但由于siRNA具有强亲水性和电负性,易被核酸酶降解及难以突破皮肤角质层屏障作用等缺陷,使其应用受到极大限制,因此,亟需安全高效的传递系统将siRNA靶向导入细胞。该文对关于应用纳米载体携载siRNA制备经皮给药系统用于皮肤疾病治疗的文献进行综述,以期为皮肤疾病治疗提供更安全、有效、实用的给药方法。Small interfering RNA(siRNA)regulates gene expression through a mechanism of RNA interference(RNAi),which specifically degrades target messenger RNA(mRNA)and has recently been used in the treatment of various skin diseases.However,due to the strong hydrophilicity and electronegativity,siRNA is easily degraded by nucleases and difficult to transduce across the barrier of the skin cuticle,which limits its clinical applications.Therefore,the need for a safe and efficient delivery system is urgent.This article reviews the recent literatures on the preparation of transdermal drug delivery system using nano-carrier carrying siRNA for the treatment of skin diseases,with the perspective for providing safer,more effective,and more practical methods for drug delivery in the treatment of skin diseases.

关 键 词：纳米载体 经皮给药系统 小干扰RNA 皮肤疾病 

分 类 号：R986[医药卫生—药品] TQ460.6[医药卫生—药学]