胎儿纤维连接蛋白检测对早产的预测价值研究  

Study on the predictive value of fetal fibronectin test for preterm delivery

作　　者：潘明珍 PAN Ming-zhen(Xingyi People’s Hospital,Xingyi 562400,China)

机构地区：[1]贵州省兴义市人民医院产科,562400

出　　处：《中国实用医药》2021年第24期56-58,共3页China Practical Medicine

摘　　要：目的评估胎儿纤维连接蛋白(fFN)检测对早产的预测价值。方法220例早产高危孕妇,检测其阴道分泌物中的fFN,同时阴道超声测量宫颈长度(CL)。追踪孕妇的妊娠结局,对孕妇的妊娠结局进行追踪,对不同fFN及CL检测结果孕妇7 d内、7~14 d内、15 d~37周内早产发生情况进行统计。并计算f FN检测对于早产的敏感度、特异度、阳性预测值和阴性预测值。结果220例早产高危孕妇中,87例早产,133例足月分娩。fFN检测结果显示:f FN阳性94例,fFN阴性126例。在7 d内、7~14 d内、15 d~37周内fFN阳性的早产率分别为17.0%、25.5%、38.3%,均高于fFN阴性的0.8%、1.6%、6.3%,差异有统计学意义(P<0.05)。阴道超声CL检测结果显示,阳性88例,阴性132例。在7 d内、7~14 d内、15 d~37周内CL阳性的早产率分别为19.3%、26.1%、31.8%,均高于CL阴性的0、2.3%、12.1%,差异有统计学意义(P<0.05)。fFN检测对早产预测的灵敏度为87.4%(76/87),特异度为86.5%(115/133),阳性预测值为80.9%(76/94);阴性预测值为91.3%(115/126)。结论对于早产高危孕妇检测其阴道分泌物中的fFN,可为早产预测提供一定的参考依据,有临床推广应用价值。Objective To evaluate the predictive value of fetal fibronectin(fFN)test for preterm delivery.Methods There were 220 pregnant women with high risk of preterm delivery.The fFN in vaginal secretion was detected,and the cervical length(CL)was measured by transvaginal ultrasound.The pregnancy outcomes of pregnant women were followed up,and the occurrence of preterm delivery in pregnant women with different fFN and CL test results within 7 d,7-14 d,and 15 d-37 weeks was counted.The sensitivity,specificity,positive predictive value and negative predictive value of fFN test for prediction of preterm delivery were calculated.Results Among 220 cases of high-risk preterm delivery,there were 87 cases of premature delivery,133 cases of full-term delivery.The fFN test results showed that 94 cases were positive for fFN and 126 cases were negative for fFN.Within 7 d,7-14 d and 15-37 weeks after CL measurement,the preterm birth rates of those with positive fFN were 17.0%,25.5%and 38.3%respectively,which were higher than 0.8%,1.6%and 6.3%of those with negative fFN,and the difference was statistically significant(P<0.05).The results of CL examination by vaginal ultrasound showed that 88 cases were positive and 132 were negative.The preterm birth rates of those with positive CL within 7 d,7-14 d,and 15-37 weeks after CL measurement were 19.3%,26.1%,and 31.8%,respectively,which were higher than 0,2.3%,and 12.1%of those with negative CL,and the difference was statistically significant(P<0.05).The sensitivity of fFN test for predicting preterm delivery was 87.4%(76/87),the specificity was 86.5%(115/133),the positive predictive value was 80.9%(76/94);the negative predictive value was 91.3%(115/126).Conclusion The detection of fFN in vaginal secretions of high-risk pregnant women with preterm delivery can provide a certain reference for the prediction of premature delivery basis,and has clinical promotion and application value.

关 键 词：早产 胎儿纤维连接蛋白 宫颈长度 预测 阳性 阴性 

分 类 号：R714.21[医药卫生—妇产科学]