评价LISA技术治疗新生儿呼吸窘迫综合征的临床疗效  

Evaluation on clinical efficacy of LISA technology in the treatment of neonatal respiratory distress syndrome

作　　者：陈先寨 CHEN Xian-zhai(People’s Hospital of Liwan District,Guangzhou 510000,China)

机构地区：[1]广州市荔湾区人民医院,510000

出　　处：《中国实用医药》2021年第24期122-124,共3页China Practical Medicine

摘　　要：目的评价新生儿呼吸窘迫综合征(NRDS)患儿采用微创注入肺表面活性物质(LISA)技术治疗的临床效果。方法80例NRDS患儿,随机分为对照组和实验组,各40例。对照组患儿采用气管插管-肺表面活性物质-拔管后经鼻持续气道正压通气(INSURE)技术治疗,实验组患儿在INSURE技术基础上加用LISA技术治疗。比较两组临床疗效、血气指标(二氧化碳分压、氧分压、氧合指数、血氧饱和度)及并发症发生率。结果实验组治疗总有效率95.00%高于对照组的72.50%,差异有统计学意义(P<0.05)。治疗前,两组二氧化碳分压、氧分压、氧合指数及血氧饱和度比较差异无统计学意义(P>0.05);治疗后,两组二氧化碳分压、氧分压、氧合指数及血氧饱和度均优于治疗前,且实验组二氧化碳分压(36.87±2.28)mm Hg(1 mm Hg=0.133 kPa)、氧分压(98.15±5.54)mm Hg、氧合指数(369.13±36.85)mm Hg及血氧饱和度(97.83±14.29)%均优于对照组的(40.13±2.33)mm Hg、(80.61±6.67)mm Hg、(317.25±30.91)mm Hg、(87.52±13.58)%,差异有统计学意义(P<0.05)。两组气漏综合征、新生儿持续肺动脉高压(PPHN)、动脉导管未闭(PDA)、肺出血、视网膜病变(ROP)、脑室周围白质软化症(PVL)发生率比较差异均无统计学意义(P>0.05)。结论对NRDS患儿采用LISA技术治疗,可有效改善患儿的血气指标,对于提高治疗效果、改善预后具有重要意义,值得推广。Objective To evaluate the clinical effect of less-invasive surfactant administration(LISA)technology in the treatment of neonatal respiratory distress syndrome(NRDS).Methods A total of 80 children with NRDS were randomly divided into control group and experimental group,with 40 cases in each group.The control group was treated with intubation-surfactant-extubation(INSURE)technology,and the experimental group was treated with LISA based on the LISA.The clinical efficacy,blood gas indexes(partial pressure of carbon dioxide,partial pressure of oxygen,oxygenation index,blood oxygen saturation),and occurrence of adverse reactions were compared between the two groups.Results The total effective rate 95.00%of the experimental group was higher than 72.50%in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in partial pressure of carbon dioxide,partial pressure of oxygen,oxygenation index and blood oxygen saturation between the two groups(P>0.05).After treatment,the partial pressure of carbon dioxide,partial pressure of oxygen,oxygenation index and blood oxygen saturation of the two groups were better than those before treatment,and the partial pressure of carbon dioxide(36.87±2.28)mm Hg(1 mm Hg=0.133 kPa),partial pressure of oxygen(98.15±5.54)mm Hg,oxygenation index(369.13±36.85)mm Hg and blood oxygen saturation(97.83±14.29)%of the experimental group were better than(40.13±2.33)mm Hg,(80.61±6.67)mm Hg,(317.25±30.91)mm Hg and(87.52±13.58)%of the control group.All the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of air leak syndrome,persistent pulmonary hypertension(PPHN),patent ductus arteriosus(PDA),pulmonary hemorrhage,retinopathy(ROP),and periventricular leukomalacia(PVL)between the two groups(P>0.05).Conclusion The application of LISA technology can effectively improve the blood gas indexes of children with neonatal respiratory distress syndrome.It i

关 键 词：新生儿呼吸窘迫综合征 微创注入肺表面活性物质技术 气管插管-肺表面活性物质-拔管后经鼻持续气道正压通气技术 

分 类 号：R722.1[医药卫生—儿科]