基于“五原则”的血必净注射液质量标志物的预测分析  

Predictive analysis of quality marker in Xuebijing Injection based on“five principles”

作　　者：蔡楠 曹宁宁 赵利斌 裴帅[1] 李晓璇 张琬靖 肖学凤[1] 刘昌孝[4] CAI Nan;CAO Ningning;ZHAO Libin;PEI Shuai;LI Xiaoxuan;ZHANG Wanjing;XIAO Xuefeng;LIU Changxiao(School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Traditional Chinese Medicine Research Center,Tasly Holding Group Co.Ltd.,Tianjin 300410,China;Zhendong Guangming Pharmaceutical Research Institute,Beijing 100085,China;State Key Laboratory of Drug Delivery Technology and Pharmacokinetics,Tianjin Institute of Pharmaceutical Research,Tianjin 300301,China)

机构地区：[1]天津中医药大学中药学院,天津301617 [2]天士力控股集团有限公司研究院现代中药开发中心,天津300410 [3]北京振东光明药物研究院,北京100085 [4]天津药物研究院释药技术与药物代谢动力学国家重点实验室,天津300301

出　　处：《天津中医药》2021年第8期1062-1070,共9页Tianjin Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81973557);天津市自然科学基金重点项目(20JCZDJC00010);国家科技重大专项项目(2018ZX09737-019,2018ZX09303-024);天津中医药大学研究生科研创新项目(YJSKC-20201013)。

摘　　要：[目的]基于中药质量标志物(Q-marker)“五原则”——传递与溯源、特有性、有效性、复方配伍环境及可测性,对血必净注射液的Q-marker进行研究。[方法]通过中国知网(CNKI)、万方、Pumbed、Medline等数据库,检索血必净注射液的化学成分、药代动力学、药理作用、临床应用以及质量控制等相关文献,并在此基础上,基于Q-marker的“五原则”,预测分析血必净注射液的Q-marker。[结果]羟基红花黄色素A、丹酚酸B、芍药苷、洋川芎内酯I、洋川芎内酯H可作为血必净注射液的Q-marker。[结论]研究预测了血必净注射液的Q-marker,为后续临床及质量控制研究提供参考依据。[Objective]To explore the quality marker(Q-marker)of Xuebijing Injection based on the“five principles”of Q-marker of traditional Chinese medicine:transmission and traceability,specificity,effectiveness,measurability and compatibility environment of compound prescriptions.[Methods]The relevant literature on the chemical constituents,pharmacokinetics,pharmacological activities,clinical application and quality control of Xuebijing Injection were retrieved in the databases such as CNKI,Wanfang,Pumbed and Medline.On the basis of this,the Q-marker of Xuebijing Injection are predicted and analyzed based on the“five principles”of Q-marker of traditional Chinese medicine.[Results]The hydroxysafflor yellow A,salvianolic acid B,paeoniflorin,senkyunolide I and senkyunolide H could be used as Q-marker of Xuebijing Injection.[Conclution]This study predicted the Q-marker of Xuebijing Injection,which could provide reference for its follow-up clinical and quality control research.

关 键 词：血必净注射液 质量标志物 五原则 

分 类 号：R28[医药卫生—中药学]