高氧诱导肺血管内皮细胞损伤与支气管肺发育不良的研究进展  

Research progresses of hyperoxia-induced injury of pulmonary vascular endothelial cells in bronchopulmonary dysplasia

作　　者：王思思 伍金林 Wang Sisi;Wu Jinlin(Department of Neonatology,Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University),Ministry of Education,West China Second University Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China)

机构地区：[1]四川大学华西第二医院新生儿科、出生缺陷与相关妇儿疾病教育部重点实验室,成都610041

出　　处：《中华妇幼临床医学杂志（电子版）》2021年第3期368-372,共5页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：四川省科技厅应用基础研究项目(2021YJ0211);四川省卫健委普及应用项目(20PJ070)。

摘　　要：支气管肺发育不良(BPD)常见于需要氧疗的早产儿,而高氧应激反应的主要靶细胞为肺血管内皮细胞(PVEC)。笔者拟就高氧对PVEC的生理功能、代谢过程及PVEC内信号分子改变,在BPD发生、发展中作用的研究进展进行综述。Bronchopulmonary dysplasia(BPD)is common in preterm infants who need oxygen therapy,and pulmonary vascular endothelial cells(PVEC)are the main target cells of hyperoxia stress response.This review focuses on the research progresses of physiological function,metabolic process and signal molecule changes of PVEC induced by hyperoxia in occurrence and development of BPD.

关 键 词：支气管肺发育不良 肺 内皮细胞 血管重构 高氧症 病因学 婴儿 早产 

分 类 号：R722.6[医药卫生—儿科]